The endotoxic properties of lysates of group A hemolytic streptococci.

The Journal of experimental medicine ·Vol. 104 ·No. 6 ·1956-12-01 ·Pages 921-34

STETSON CA

Abstract

Suspensions of group A streptococci were subjected to mechanical disruption by shaking with glass beads. The supernatant solutions produced severe delayed inflammatory reactions on intradermal injection into normal rabbits. Intravenous injections caused systemic reactions characterized by fever, leucopenia, and peripheral vasomotor phenomena. These effects were more pronounced in rabbits which had previously been infected with group A streptococci. The local and generalized Shwartzman phenomena were reproduced with these crude streptococcal lysates, and the data suggest that streptococci possess an endotoxin similar to those of Gram-negative bacterial species.

Keywords

STREPTOCOCCAL INFECTIONS/experimental

MeSH Terms

Animals Endotoxins Fever Rabbits Shwartzman Phenomenon Streptococcal Infections Streptococcus pyogenes

Chemicals

Endotoxins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

STETSON C A

References (14)

14 references, click to expand

The production of complete antigens from polysaccharide haptenes by streptococci and other organisms.
J Pathol Bacteriol. 1952 Oct;64(4):775-83 PMID: 13000591
Studies on the generalized Shwartzman reaction. III. Lesions of the myocardium and coronary arteries accompanying the reaction in rabbits prepared by infection with group A streptococci.
J Exp Med. 1953 May;97(5):751-66 PMID: 13052831
Generalized Shwartzman reaction. V. Intravenous injection of collidal iron or carbon on response of rabbits to meningococcal toxin.
Proc Soc Exp Biol Med. 1953 Apr;82(4):712-5 PMID: 13055980
Production of generalized Shwartzman reaction with group A streptococcal factors.
Proc Soc Exp Biol Med. 1953 Apr;82(4):754-61 PMID: 13055991
The physiological disturbances produced by endotoxins.
Annu Rev Physiol. 1954;16:467-90 PMID: 13171836
Cold-precipitation by heparin of a protein in rabbit and human plasma.
Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):813-8 PMID: 13204363
TOLERANCE TO BACTERIAL PYROGENS : II. ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM.
J Exp Med. 1947 Jun 30;86(1):39-44 PMID: 19871653
EXPERIMENTAL GLOMERULONEPHRITIS INDUCED IN RABBITS WITH THE ENDOTOXIC PRINCIPLE OF STREPTOCOCCUS SCARLATINAE.
J Exp Med. 1926 Sep 30;44(4):567-80 PMID: 19869207
Conversion of tissue polysaccharides to auto-antigens by group-A beta-haemolytic streptococci.
Lancet. 1952 Sep 6;2(6732):449-51 PMID: 14956038
The effect of cortisone on the Shwartzman reaction; the production of lesions resembling the dermal and generalized Shwartzman reactions by a single injection of bacterial toxin in cortisone-treated rabbits.
J Exp Med. 1952 Apr;95(4):409-28 PMID: 14938509
The properties and biologic effects of bacterial pyrogens.
Medicine (Baltimore). 1950 Dec;29(4):365-400 PMID: 14796349
Studies on the O antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigens by the purified lipopolysaccharide.
J Exp Med. 1956 Feb 1;103(2):225-46 PMID: 13286429
Studies on the generalized Shwartzman reaction. VII. The role of fibrinogen in the deposition of fibrinoid after combined injections of endotoxin and synthetic acidic polymer.
J Exp Med. 1955 Sep 1;102(3):263-78 PMID: 13252182
Effect of meningococcal endotoxin on the immune response.
Proc Soc Exp Biol Med. 1955 Nov;90(2):355-60 PMID: 13273447

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.104.6.921

Published

1956-12-01

Pages

921-34

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2136644

Subset

External Links

PubMed source DOI: 10.1084/jem.104.6.921 PMC Full Text View journal details

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The endotoxic properties of lysates of group A hemolytic streptococci.

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