Catalysis by site-specific recombinases.

Trends in genetics : TIG ·Vol. 8 ·No. 12 ·1992-12-00 ·Pages 432-9

Stark WM, Boocock MR, Sherratt DJ

Abstract

Site-specific recombination reactions bring about controlled rearrangements of DNA molecules by cutting the DNA at precise points and rejoining the ends to new partners. The recombinases that catalyse these reactions can be grouped into two families by amino acid sequence homology. We describe our current understanding of how these proteins catalyse recombination, and show how the catalytic mechanisms of the two families differ.

MeSH Terms

Bacterial Proteins/genetics,metabolism Base Sequence Catalysis DNA/genetics,metabolism DNA Nucleotidyltransferases/classification,genetics,metabolism DNA Transposable Elements DNA, Circular/metabolism Gene Rearrangement Integrases Molecular Sequence Data Multigene Family Nucleotidyltransferases/genetics,metabolism Protein Binding Recombinases Recombination, Genetic Sequence Homology, Nucleic Acid Substrate Specificity Transposases Viral Proteins/genetics,metabolism

Chemicals

Bacterial Proteins DNA Transposable Elements DNA, Circular Recombinases Viral Proteins DNA DNA Nucleotidyltransferases Integrases Nucleotidyltransferases Transposases integron integrase IntI1

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Stark W M

Department of Genetics, University of Glasgow, UK.

Boocock M R

Sherratt D J

Article Info

Journal

Trends in genetics : TIG

Abbr.

Trends Genet

ISSN

0168-9525

Published

1992-12-00

Pages

432-9

Language

English

Region

England

NLM ID

8507085

Subset

Corrections

ErratumIn

External Links

PubMed source View journal details

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Catalysis by site-specific recombinases.

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