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PMID: 133609 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cytogenetic darkroom magic: now you see them, now you don't.

American journal of human genetics ·Vol. 28 ·No. 4 ·1976-07-00 ·Pages 417-9

Overton KM, Magenis RE, Brady T, Chamberlin J, Parks M

Abstract

Customary procedures used to determine chromosomal inheritance do not disclose many of the chromosomal polymorphisms known to be present, resulting in uninformative families. The sequential printing of individual chromosomes presented here is a technique that has increased the number of informative families in our studies. This technique has revealed previously unseen heritable chromosome differences and allowed the designation of parental origin.

MeSH Terms
Chromosomes, Human, 21-22 and Y Down Syndrome/genetics Humans Karyotyping/methods Quinacrine Mustard Trisomy
Chemicals
Quinacrine Mustard
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Overton K M
Magenis R E
Brady T
Chamberlin J
Parks M
References (4)
4 references, click to expand
  1. Chromosome preparations of leukocytes cultured from human peripheral blood.
    Exp Cell Res. 1960 Sep;20:613-6 PMID: 13772379
  2. Origin of extra chromosome in trisomy 21.
    Lancet. 1973 Jan 20;1(7795):131-3 PMID: 4118469
  3. Origin of extra chromosome in trisomy 21.
    Lancet. 1973 Mar 3;1(7801):487 PMID: 4120400
  4. The 24 fluorescence patterns of the human metaphase chromosomes - distinguishing characters and variability.
    Hereditas. 1972;67(1):89-102 PMID: 4142006
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1976-07-00
Pages
417-9
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685056
Subset
IM
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