Detection of JC virus in the brains of aged patients without progressive multifocal leukoencephalopathy by the polymerase chain reaction and Southern hybridization analysis.

Neuroscience letters ·Vol. 141 ·No. 2 ·1992-07-20 ·Pages 151-5

Mori M, Aoki N, Shimada H, Tajima M, Kato K

Abstract

Ninety-one brain tissue sections taken at autopsy from 33 elderly patients (63-100 years old) without progressive multifocal leukoencephalopathy were examined for the presence of JC virus DNA by the polymerase chain reaction and Southern hybridization analysis after DNA extraction. JC virus DNA was detected in 15 sections from 10 patients. These results suggest that JC virus is frequently present in the brains of aged patients.

MeSH Terms

Aged Aged, 80 and over Aging Base Sequence Brain/embryology,metabolism DNA, Viral/analysis Fetus/metabolism Humans JC Virus/isolation & purification Leukoencephalopathy, Progressive Multifocal/microbiology Middle Aged Molecular Probes/genetics Molecular Sequence Data Nucleic Acid Hybridization Polymerase Chain Reaction

Chemicals

DNA, Viral Molecular Probes

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Mori M

Tokyo Metropolitan Geriatric Hospital, Japan.

Aoki N

Shimada H

Tajima M

Kato K

Article Info

Journal

Neuroscience letters

Abbr.

Neurosci Lett

ISSN

0304-3940

DOI

10.1016/0304-3940(92)90883-9

Published

1992-07-20

Pages

151-5

Language

English

Region

Ireland

NLM ID

7600130

Subset

External Links

PubMed source DOI: 10.1016/0304-3940(92)90883-9 View journal details

Analysis Services

Detection of JC virus in the brains of aged patients without progressive multifocal leukoencephalopathy by the polymerase chain reaction and Southern hybridization analysis.

Contact

WeChat Official Account