In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+.

Journal of neural transmission. General section ·Vol. 89 ·No. 1-2 ·1992-00-00 ·Pages 139-45

Obata T, Chiueh CC

Abstract

Increased formation of hydroxyl free radicals (.OH) reflected by .OH adduct of salicylate in brain dialysate was demonstrated during the sustained (more than 2 hours) dopamine overflow elicited by 75 nmol of 1-methyl-4-phenyldihydropyridine (MPDP+) and 1-methyl-4-phenylpyridinium (MPP+) in the rat striatum. Owing to its weak dopamine releasing action, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) did not significantly increase the .OH formation. This data suggests that sustained elevation of dopamine in the extracellular fluid elicited by MPTP analogues can be auto-oxidized, which in turn leads (possibly by indirect mechanisms) to the formation of cytotoxic .OH free radicals near the nigrostriatal terminals.

MeSH Terms

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology Animals Corpus Striatum/metabolism Dialysis Dopamine/physiology Free Radicals Hydroxides/metabolism Hydroxyl Radical Male Nerve Endings/drug effects,metabolism Perfusion Pyridinium Compounds/pharmacology Rats Rats, Sprague-Dawley Salicylates/pharmacology Salicylic Acid Substantia Nigra/drug effects,metabolism

Chemicals

Free Radicals Hydroxides Pyridinium Compounds Salicylates Hydroxyl Radical 1-(4-methoxyphenyl)pyridinium 1-methyl-4-phenyl-2,3-dihydropyridinium 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Salicylic Acid Dopamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Obata T

National Institute of Neurological Disorders and Stroke, Bethesda, Md.

Chiueh C C

References (31)

31 references, click to expand

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Article Info

Journal

Journal of neural transmission. General section

Abbr.

J Neural Transm Gen Sect

DOI

10.1007/BF01245361

Published

1992-00-00

Pages

139-45

Language

English

Region

Austria

NLM ID

9002201

Subset

External Links

PubMed source DOI: 10.1007/BF01245361

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In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+.

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