Immunohistochemical analysis of nm23 gene product/NDP kinase expression in pulmonary adenocarcinoma: lack of prognostic value.

British journal of cancer ·Vol. 66 ·No. 3 ·1992-09-00 ·Pages 533-6

Higashiyama M, Doi O, Yokouchi H, Kodama K, Nakamori S, Tateishi R, Kimura N

Abstract

Levels of nm23 gene product/nucleoside diphosphate kinase (NDP kinase) expression have been demonstrated to correlate inversely with metastatic potential in several tumours, indicating that this could be a useful tool as a prognostic indicator. Using an antibody to NDP kinase, levels of nm23 gene product/NDP kinase expression in pulmonary adenocarcinoma were examined immunohistochemically. Of 88 patients tested, 39 (44%; Group B) showed strong immunoreactivity for NDP kinase in most of cancer cells within the tumour tissues, while 49 (56%; Group A) contained few or no NDP kinase-positive cancer cells. Nm23 gene product/NDP kinase was expressed independently of clinicopathological factors, and unexpectedly, no correlation of survival rates between both Groups could be demonstrated. Thus, in pulmonary adenocarcinoma, levels of nm23 gene product/NDP kinase expression may lack prognostic value.

MeSH Terms

Adenocarcinoma/chemistry,mortality,pathology Adult Aged Female Humans Immunohistochemistry Lung Neoplasms/chemistry,mortality,pathology Male Middle Aged Monomeric GTP-Binding Proteins NM23 Nucleoside Diphosphate Kinases Nucleoside-Diphosphate Kinase/analysis Prognosis Proteins/analysis Survival Rate Transcription Factors

Chemicals

NM23 Nucleoside Diphosphate Kinases Proteins Transcription Factors NME1 protein, human Nucleoside-Diphosphate Kinase Monomeric GTP-Binding Proteins

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Higashiyama M

Department of Surgery, Center for Adult Diseases, Osaka, Japan.

Doi O

Yokouchi H

Kodama K

Nakamori S

Tateishi R

Kimura N

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Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1992.308

Published

1992-09-00

Pages

533-6

Language

English

Region

England

NLM ID

0370635

PMCID

PMC1977950

Subset

External Links

PubMed source DOI: 10.1038/bjc.1992.308 PMC Full Text View journal details

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Immunohistochemical analysis of nm23 gene product/NDP kinase expression in pulmonary adenocarcinoma: lack of prognostic value.

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