Detection of JC virus by polymerase chain reaction in cerebrospinal fluid from two patients with progressive multifocal leukoencephalopathy.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology ·Vol. 11 ·No. 3 ·1992-03-00 ·Pages 253-4

Telenti A, Marshall WF, Aksamit AJ, Smilack JD, Smith TF

Abstract

The polymerase chain reaction (PCR) was used to identify JC virus (JCV) in the cerebrospinal fluid of two patients with progressive multifocal leukoencephalopathy confirmed by brain biopsy. In addition, JCV viremia was demonstrated by PCR in one case. JCV detection in spinal fluid by PCR may be the first non-invasive technique available for the diagnostic confirmation of progressive multifocal leukoencephalopathy.

MeSH Terms

DNA, Viral/cerebrospinal fluid Humans JC Virus/isolation & purification Leukoencephalopathy, Progressive Multifocal/cerebrospinal fluid,microbiology Polymerase Chain Reaction Tumor Virus Infections/cerebrospinal fluid,microbiology Viremia/microbiology

Chemicals

DNA, Viral

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Telenti A

Institute of Medical Microbiology, University of Berne, Switzerland.

Marshall W F

Aksamit A J

Smilack J D

Smith T F

References (13)

13 references, click to expand

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Article Info

Journal

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Abbr.

Eur J Clin Microbiol Infect Dis

ISSN

0934-9723

DOI

10.1007/BF02098091

Published

1992-03-00

Pages

253-4

Language

English

Region

Germany

NLM ID

8804297

Subset

External Links

PubMed source DOI: 10.1007/BF02098091 View journal details

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Detection of JC virus by polymerase chain reaction in cerebrospinal fluid from two patients with progressive multifocal leukoencephalopathy.

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