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PMID: 1317508 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Proteolysis, proteasomes and antigen presentation.

Nature ·Vol. 357 ·No. 6377 ·1992-06-04 ·Pages 375-9

Goldberg AL, Rock KL

Abstract

Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that degrade cytosolic and nuclear proteins. These particles have been implicated in ATP-ubiquitin-dependent proteolysis and in the processing of intracellular antigens for cytolytic immune responses.

Keywords

NASA Discipline Musculoskeletal Non-NASA Center

MeSH Terms

Adenosine Triphosphate/metabolism,pharmacology Antigen-Presenting Cells/immunology Antigens/immunology,metabolism Endopeptidases/metabolism Proteins/metabolism T-Lymphocytes/immunology Ubiquitins/pharmacology

Chemicals

Antigens Proteins Ubiquitins Adenosine Triphosphate Endopeptidases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Goldberg A L

Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, Massachusetts.

Rock K L

Investigators

1 investigators, click to expand

Goldberg A L

Harvard Med Sch, Boston, MA

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/357375a0

Published

1992-06-04

Pages

375-9

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/357375a0 View journal details

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Proteolysis, proteasomes and antigen presentation.

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