A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor.

FEBS letters ·Vol. 300 ·No. 3 ·1992-04-06 ·Pages 237-40

Bork P, Sander C

Abstract

A new family of mosaic proteins is defined by sequence analysis. The family is characterized by a 260 residue domain common to proteins of apparently diverse function and tissue specificity: sperm receptors Zp2 and Zp3, betaglycan (also called TGF-beta type III receptor), uromodulin, as well as the major zymogen granule membrane protein (GP-2). The location of the common domain is similar with respect to putative transmembrane regions. The results lead to the hypothesis that this type of domain has a common tertiary structure and that there is a functional similarity in the recognition mechanism of the sperm receptor system and the TGF-beta receptor complex.

MeSH Terms

Amino Acid Sequence Animals Cricetinae Dogs Egg Proteins Female Glycoproteins/chemistry,genetics Humans Male Membrane Glycoproteins Membrane Proteins/chemistry Mice Molecular Sequence Data Protein Conformation Proteoglycans/chemistry Rats Receptors, Cell Surface/chemistry,genetics Receptors, Transforming Growth Factor beta Sequence Alignment Sequence Homology, Nucleic Acid Software Spermatozoa/chemistry Structure-Activity Relationship Transforming Growth Factor beta/chemistry,genetics Zona Pellucida Glycoproteins

Chemicals

Egg Proteins Glycoproteins Membrane Glycoproteins Membrane Proteins Proteoglycans Receptors, Cell Surface Receptors, Transforming Growth Factor beta Transforming Growth Factor beta ZP2 protein, human ZP3 protein, human Zona Pellucida Glycoproteins Zp2 protein, mouse Zp3 protein, mouse betaglycan

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bork P

EMBL, Heidelberg, Germany.

Sander C

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(92)80853-9

Published

1992-04-06

Pages

237-40

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(92)80853-9 View journal details

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A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor.

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