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PMID: 1309723 Published · ppublish English Journal Article

Role of superoxide dismutase in resistance of Porphyromonas gingivalis to killing by polymorphonuclear leukocytes.

Infection and immunity ·Vol. 60 ·No. 2 ·1992-02-00 ·Pages 712-4

Amano A, Ishimoto T, Tamagawa H, Shizukuishi S

Abstract

Porphyromonas gingivalis in which the synthesis of superoxide dismutase (SOD) was induced by nitrate or by aeration was rendered resistant to killing by polymorphonuclear leukocytes. SOD purified from either anaerobically maintained or aerated cells also inhibited bacterial killing when added exogenously, and no difference between the effects of the two SODs was observed. These results suggest that SOD may form part of a defense mechanism that helps protect P. gingivalis against killing by polymorphonuclear leukocytes.

MeSH Terms
Blood Bactericidal Activity Humans Neutrophils/immunology Phagocytosis Porphyromonas gingivalis/immunology Superoxide Dismutase/physiology
Chemicals
Superoxide Dismutase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Amano A
Department of Preventive Dentistry, Osaka University Faculty of Dentistry, Japan.
Ishimoto T
Tamagawa H
Shizukuishi S
References (23)
23 references, click to expand
  1. Superoxide dismutase and oxygen toxicity defenses in the genus Neisseria.
    Infect Immun. 1986 Feb;51(2):631-41 PMID: 3943903
  2. Antiphagocytic effects of the capsular structure of a pathogenic strain of Bacteroides melaninogenicus.
    Bull Tokyo Dent Coll. 1973 Aug;14(3):99-104 PMID: 4519681
  3. In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood.
    J Clin Invest. 1967 Apr;46(4):668-79 PMID: 6021213
  4. Catalase and superoxide dismutase in Escherichia coli.
    J Biol Chem. 1983 May 25;258(10):6277-81 PMID: 6304032
  5. Resistance of Nocardia asteroides to oxygen-dependent killing by neutrophils.
    J Infect Dis. 1983 Nov;148(5):861-7 PMID: 6355320
  6. Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: virulence factors in colonization, survival, and tissue destruction.
    J Dent Res. 1984 Mar;63(3):412-21 PMID: 6583243
  7. Relationship between superoxide dismutase and pathogenic mechanisms of Listeria monocytogenes.
    Infect Immun. 1979 Mar;23(3):863-72 PMID: 110685
  8. Antibody-dependent alternate pathway of complement activation in opsonophagocytosis of Porphyromonas gingivalis.
    Infect Immun. 1991 Jun;59(6):2105-9 PMID: 2037371
  9. Contribution of superoxide dismutase and catalase activities to Shigella flexneri pathogenesis.
    Infect Immun. 1990 Feb;58(2):529-35 PMID: 2404874
  10. The effect of periodontal proteolytic Bacteroides species on proteins of the human complement system.
    J Periodontal Res. 1988 May;23(3):187-92 PMID: 2969970
  11. Inductions of superoxide dismutases in Escherichia coli under anaerobic conditions. Accumulation of an inactive form of the manganese enzyme.
    J Biol Chem. 1988 Mar 25;263(9):4274-9 PMID: 3279033
  12. Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque.
    J Immunol Methods. 1974 Aug;5(3):249-52 PMID: 4427075
  13. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).
    J Biol Chem. 1969 Nov 25;244(22):6049-55 PMID: 5389100
  14. Virulence of black-pigmented Bacteroides strains from periodontal pockets and other sites in experimentally induced skin lesions in mice.
    J Periodontal Res. 1982 Jan;17(1):41-9 PMID: 6123563
  15. The role of oxygen and its derivatives in microbial pathogenesis and host defense.
    Annu Rev Microbiol. 1984;38:27-48 PMID: 6388493
  16. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
    Anal Biochem. 1976 May 7;72:248-54 PMID: 942051
  17. Catalase, superoxide dismutase, and virulence of Staphylococcus aureus. In vitro and in vivo studies with emphasis on staphylococcal--leukocyte interaction.
    J Clin Invest. 1975 Mar;55(3):561-6 PMID: 1117067
  18. Phagocytosis of virulent Porphyromonas gingivalis by human polymorphonuclear leukocytes requires specific immunoglobulin G.
    Infect Immun. 1991 Jun;59(6):2097-104 PMID: 2037370
  19. Characterization of superoxide dismutases purified from either anaerobically maintained or aerated Bacteroides gingivalis.
    J Bacteriol. 1990 Mar;172(3):1457-63 PMID: 2307656
  20. Failure of Bacteroides gingivalis W83 to accumulate bound C3 following opsonization with serum.
    J Periodontal Res. 1989 Jan;24(1):20-7 PMID: 2524566
  21. Further studies on the degradation of immunoglobulins by black-pigmented Bacteroides.
    Oral Microbiol Immunol. 1989 Mar;4(1):12-8 PMID: 2628862
  22. Relationship between enzyme activities involved in oxygen metabolism and oxygen tolerance in black-pigmented Bacteroides.
    J Dent Res. 1988 Sep;67(9):1196-9 PMID: 3166001
  23. The presence of bacteria within the oral epithelium in periodontal disease. I. A scanning and transmission electron microscopic study.
    J Periodontol. 1985 Oct;56(10):618-24 PMID: 3863912
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.60.2.712-714.1992
Published
1992-02-00
Pages
712-4
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC257691
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.60.2.712-714.1992 PMC Full Text View journal details
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