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PMID: 1309450 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Hepatitis B virus markers and antibodies to hepatitis C virus in Japanese patients with hepatocellular carcinoma.

Digestive diseases and sciences ·Vol. 37 ·No. 1 ·1992-01-00 ·Pages 65-72

Yuki N, Hayashi N, Kasahara A, Hagiwara H, Katayama K, Fusamoto H, Kamada T

Abstract

Sera from Japanese patients with chronic liver disease were tested for hepatitis B virus (HBV) markers and antibodies to hepatitis C virus (anti-HCV), and the results were correlated to the presence of hepatocellular carcinoma. In chronic non-A, non-B liver disease, anti-HCV prevalence was high both in patients with hepatocellular carcinoma (78/89, 88%) and without it (66/84, 79%), while previous HBV infection was more common in patients with hepatocellular carcinoma (65/89, 73%) than in those without it (46/84, 55%) (P less than 0.05). Coexistence of anti-HCV and antibodies to HBV was observed frequently in patients with hepatocellular carcinoma (56/89, 63%) compared with patients without it (39/84, 46%) (P less than 0.05). In chronic HBV carriers, anti-HCV was more common in patients with hepatocellular carcinoma (12/38, 32%) than in those without it (3/62, 5%) (P less than 0.01). These results suggest that infection with the two viruses may be a risk factor for more serious liver disease.

MeSH Terms
Aged Antigens, Viral Biomarkers Carcinoma, Hepatocellular/immunology Enzyme-Linked Immunosorbent Assay Female Hepacivirus/immunology Hepatitis Antibodies/analysis Hepatitis B/classification,immunology Hepatitis B Core Antigens/analysis Hepatitis B Surface Antigens/analysis Hepatitis C/immunology Humans Liver Neoplasms/immunology Male Middle Aged Viral Nonstructural Proteins Viral Proteins/immunology
Chemicals
Antigens, Viral Biomarkers C100 protein, hepatitis C virus Hepatitis Antibodies Hepatitis B Core Antigens Hepatitis B Surface Antigens Viral Nonstructural Proteins Viral Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Yuki N
First Department of Medicine, Osaka University Medical School, Japan.
Hayashi N
Kasahara A
Hagiwara H
Katayama K
Fusamoto H
Kamada T
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Article Info
Journal
Digestive diseases and sciences
Abbr.
Dig Dis Sci
ISSN
0163-2116
DOI
10.1007/BF01308344
Published
1992-01-00
Pages
65-72
Language
English
Region
United States
NLM ID
7902782
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01308344 View journal details
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