The mechanism of action of cortisone in experimental hypersensitivity. II. Hypersensitivity of the serum sickness type.
Cortisone markedly suppressed the cardiovascular and renal lesions of serum sickness type hypersensitivity which ordinarily develop following the intravenous injection of bovine albumin. The inhibitory effect of cortisone on the allergic granulomatous lesions of the spleen was less striking; the lesions were less extensive, but the percentage of animals affected was unchanged. Cortisone in the dosage employed had no effect on the elimination of antigen following its intravenous administration or on the appearance of circulating antibody. These findings indicate that inhibition of the lesions of serum sickness by cortisone does not depend on the suppression of antibody production. Therefore, it is inferred that cortisone somehow protects the animal from the damaging effects of antigen-antibody union.
16 references, click to expand
-
Anatomic and histologic changes in rabbits with experimental hypersensitivity treated with Compound E and ACTH.Proc Soc Exp Biol Med. 1951 Jan;76(1):177-82 PMID: 14816433
-
ACTH and cortisone in allergic diseases; clinical, serologic (electrophoretic), and immunologic studies.J Allergy. 1951 May;22(3):211-36 PMID: 14841011
-
Fate of I131 labelled bovine gamma globulin in rabbits.Fed Proc. 1951 Jun;10(2):553-7 PMID: 14849612
-
The mechanism of action of 17-hydroxy-11-dehydrocorticosterone (compound E) and of the adrenocorticotropic hormone in experimental hypersensitivity in rabbits.J Exp Med. 1951 Aug;94(2):139-70 PMID: 14861375
-
The effect of ACTH and cortisone upon experimental glomerulonephritis.Trans Assoc Am Physicians. 1951;64:257-61 PMID: 14884257
-
Experimental hypersensitivity; a study in the relationship of corticotropin (ACTH) and adrenalectomy to the serologic sequence and production of pathological lesions following injection of heterologous serum protein.AMA Am J Dis Child. 1952 Jan;83(1):79-80 PMID: 14884743
-
The influence of cortisone on the evolution of acute infection and the development of immunity.Bull Johns Hopkins Hosp. 1952 Jul;91(1):22-47 PMID: 14935476
-
The occurrence of focal tuberculoid lesions in experimental serum sickness.Bull Johns Hopkins Hosp. 1952 Aug;91(2):109-23 PMID: 14944966
-
Influence of cortisone on experimental hypersensitivity and circulating antibody in the guinea pig.Proc Soc Exp Biol Med. 1952 Jun;80(2):188-91 PMID: 14948993
-
Platelet transfusions and the pathogenesis of idiopathic thrombocytopenic purpura.J Am Med Assoc. 1952 Nov 22;150(12):1193-8 PMID: 12990383
-
A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type.J Exp Med. 1953 Feb 1;97(2):257-82 PMID: 13022878
-
Effect of 17-hydroxy-11-dehydrocorticosterone (compound E) and of ACTH on arthus reaction and antibody formation in the rabbit.Proc Soc Exp Biol Med. 1950 Aug;74(4):815-23 PMID: 14781192
-
The effect of cortisone upon the experimental cardiovascular and renal lesions produced by anaphylactic hypersensitivity.Bull Johns Hopkins Hosp. 1950 Dec;87(6):549-67 PMID: 14783719
-
The treatment of acquired hemolytic anemia with adrenocorticotrophic hormone (ACTH).N Engl J Med. 1950 Jan 25;244(4):117-27 PMID: 14796796
-
Effects of cortisone, hyaluronidase, desoxycorticosterone, and artisone on experimental serum disease in rabbits.Proc Soc Exp Biol Med. 1950 Nov;75(2):337-42 PMID: 14808252
-
The effect of ACTH and cortisone upon experimental anaphylactic glomerulonephritis.Bull Johns Hopkins Hosp. 1951 Feb;88(2):189-93 PMID: 14812224
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
