Rate of cholesterol synthesis in hypo- and hyperthyroid rats.

The Journal of experimental medicine ·Vol. 96 ·No. 5 ·1952-11-00 ·Pages 513-6

BYERS SO, ROSENMAN RH, FRIEDMAN M, BIGGS MW

Abstract

The rate of cholesterol synthesis, measured by the rate of incorporation of tritium from body water into the cholesterol molecule, was found to be greater than normal in the hyperthyroid rat and below normal in the hypo-thyroid rat.

Keywords

CHOLESTEROL/in blood HYPERTHYROIDISM/metabolism in HYPOTHYROIDISM/metabolism in

MeSH Terms

Animals Cholesterol/blood Hyperthyroidism/metabolism Hypothyroidism/metabolism Rats

Chemicals

Cholesterol

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

BYERS S O

ROSENMAN R H

FRIEDMAN M

BIGGS M W

References (8)

8 references, click to expand

Changes in biliary cholesterol abnormal thyroid states.
Science. 1951 Aug 24;114(2956):210-1 PMID: 14866197
Production and excretion of cholesterol in mammals. VII. Biliary cholesterol; increment and indicator of hepatic synthesis of cholesterol.
Am J Physiol. 1952 Feb;168(2):297-302 PMID: 14903144
The role of desiccated thyroid and potassium iodide in the cholesterol-induced atherosclerosis of the chicken.
Am Heart J. 1949 Jul;38(1):25-33 PMID: 18153125
Observations with radioactive hydrogen (H3) in experimental atherosclerosis.
Circulation. 1951 Jul;4(1):34-42 PMID: 14848951
Study of extra-cellular hydration in hyperthyroidism.
Bull Mem Soc Med Hop Paris. 1949 May 6-13;65(15-16):628-35 PMID: 18153454
Synthetic L. casei Factor (Folic Acid) in Treating Certain Anemias in Man.
Science. 1946 Nov 8;104(2706):439 PMID: 17819689
The effect of thyroid activity on certain anabolic processes studied with the aid of deuterium.
J Biol Chem. 1949 Jun;179(2):819-30 PMID: 18150015
STUDIES ON THE PREVENTION OF CHOLESTEROL ATHEROSCLEROSIS IN RABBITS : I. THE EFFECTS OF WHOLE THYROID AND OF POTASSIUM IODIDE.
J Exp Med. 1933 Jun 30;58(1):115-25 PMID: 19870177

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.96.5.513

Published

1952-11-00

Pages

513-6

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2136159

Subset

External Links

PubMed source DOI: 10.1084/jem.96.5.513 PMC Full Text View journal details

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Rate of cholesterol synthesis in hypo- and hyperthyroid rats.

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