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PMID: 12973298 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The organization of the microbial biodegradation network from a systems-biology perspective.

EMBO reports ·Vol. 4 ·No. 10 ·2003-10-00 ·Pages 994-9

Pazos F, Valencia A, De Lorenzo V

Abstract

Microbial biodegradation of environmental pollutants is a field of growing importance because of its potential use in bioremediation and biocatalysis. We have studied the characteristics of the global biodegradation network that is brought about by all the known chemical reactions that are implicated in this process, regardless of their microbial hosts. This combination produces an efficient and integrated suprametabolism, with properties similar to those that define metabolic networks in single organisms. The characteristics of this network support an evolutionary scenario in which the reactions evolved outwards from the central metabolism. The properties of the global biodegradation network have implications for predicting the fate of current and future environmental pollutants.

MeSH Terms
Bacteria/metabolism Biodegradation, Environmental Databases, Factual Environmental Pollutants/metabolism Enzymes/metabolism Fungi/metabolism Hazardous Substances/metabolism Models, Theoretical Systems Theory
Chemicals
Environmental Pollutants Enzymes Hazardous Substances
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pazos Florencio
ALMA Bioinformatics, Centro Empresarial Euronova, Ronda de Poniente 4, Tres Cantos, 28760 Madrid, Spain.
Valencia Alfonso
De Lorenzo Víctor
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1038/sj.embor.embor933
Published
2003-10-00
Epub
2003-00-05
Pages
994-9
Language
English
Region
England
NLM ID
100963049
PMCID
PMC1326392
Subset
IM
Corrections
CommentIn
PMID: 14528254
External Links
PubMed source DOI: 10.1038/sj.embor.embor933 PMC Full Text View journal details
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