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PMID: 12967497 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence.

Emerging infectious diseases ·Vol. 9 ·No. 8 ·2003-08-00 ·Pages 978-84

Vandenesch F, Naimi T, Enright MC, Lina G, Nimmo GR, Heffernan H, Liassine N, Bes M, Greenland T, Reverdy ME, Etienne J

Abstract

Infections caused by community-acquired (CA)-methicillin--resistant Staphylococcus aureus (MRSA) have been reported worldwide. We assessed whether any common genetic markers existed among 117 CA-MRSA isolates from the United States, France, Switzerland, Australia, New Zealand, and Western Samoa by performing polymerase chain reaction for 24 virulence factors and the methicillin-resistance determinant. The genetic background of the strain was analyzed by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). The CA-MRSA strains shared a type IV SCCmec cassette and the Panton-Valentine leukocidin locus, whereas the distribution of the other toxin genes was quite specific to the strains from each continent. PFGE and MLST analysis indicated distinct genetic backgrounds associated with each geographic origin, although predominantly restricted to the agr3 background. Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA.

MeSH Terms
Bacterial Toxins Communicable Diseases, Emerging/epidemiology,genetics Community-Acquired Infections/epidemiology,genetics Electrophoresis, Gel, Pulsed-Field Exotoxins Humans Leukocidins/genetics Methicillin Resistance/genetics Microbial Sensitivity Tests Staphylococcus aureus/drug effects,genetics,isolation & purification
Chemicals
Bacterial Toxins Exotoxins Leukocidins Panton-Valentine leukocidin
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Vandenesch Francois
INSERM E0230, Lyon, France.
Naimi Timothy
Enright Mark C
Lina Gerard
Nimmo Graeme R
Heffernan Helen
Liassine Nadia
Bes Michèle
Greenland Timothy
Reverdy Marie-Elisabeth
Etienne Jerome
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Article Info
Journal
Emerging infectious diseases
Abbr.
Emerg Infect Dis
ISSN
1080-6040
DOI
10.3201/eid0908.030089
Published
2003-08-00
Pages
978-84
Language
English
Region
United States
NLM ID
9508155
PMCID
PMC3020611
Subset
IM
External Links
PubMed source DOI: 10.3201/eid0908.030089 PMC Full Text View journal details
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