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题目:: Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer.
作者:: Iwasa(Satoshi),Jin(Xin),Okada(Kyoko),Mitsumata(Masako),Ooi(Akishi)
状态:: 发布时间2003-09-09 , 更新时间 2015-11-19
期刊:: Cancer Lett
摘要:: Seprase is a membrane-bound serine proteinase with gelatinase activity, which may be involved in cancer invasion and metastasis. We examined seprase expression in colorectal cancer specimens obtained from 109 patients. Seprase immunoreactivity was found in cancer cells and adjacent stromal cells. Immunoblotting showed higher levels of seprase protein in colorectal cancer tissue than in normal colorectal tissue. A semiquantitative assessment of the immunohistochemistry results revealed a significant correlation between seprase expression and lymph node metastasis. These results suggested that an abundant expression of seprase in colorectal cancer tissue is associated with lymph node metastasis.
语言:: eng
DOI:

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