Prevalence of fragilysin gene in Bacteroides fragilis isolates from blood and other extraintestinal samples.

Journal of clinical microbiology ·Vol. 41 ·No. 9 ·2003-09-00 ·Pages 4428-30

Foulon I, Piérard D, Muyldermans G, Vandoorslaer K, Soetens O, Rosseel P, Lauwers S

Abstract

Of 166 Bacteroides fragilis isolates, 26.2% of 103 isolates from blood and 20.6% of 63 extraintestinal isolates harbored the fragilysin gene (difference not statistically significant). Clinical characteristics and evolution were comparable in patients with B. fragilis bacteremia with or without this enterotoxin. Fragilysin seems not to be an important virulence factor in B. fragilis disease.

MeSH Terms

Adolescent Adult Aged Aged, 80 and over Bacteremia/microbiology Bacteroides fragilis/genetics,pathogenicity Child Child, Preschool Female Humans Infant Infant, Newborn Male Metalloendopeptidases/genetics Middle Aged Virulence Factors

Chemicals

Virulence Factors Metalloendopeptidases fragilysin

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Foulon Ina

Department of Microbiology, Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium.

Piérard Denis

Muyldermans Gaëtan

Vandoorslaer Kristof

Soetens Oriane

Rosseel Paul

Lauwers Sabine

References (17)

17 references, click to expand

Detection of Pseudomonas (Burkholderia) cepacia using PCR.
Pediatr Pulmonol. 1995 Jul;20(1):44-9 PMID: 7478781
Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin.
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14979-84 PMID: 9844001
Purification and characterization of an enterotoxin from Bacteroides fragilis.
Infect Immun. 1992 Apr;60(4):1343-50 PMID: 1548060
Detection of enterotoxigenic Bacteroides fragilis and its toxin in stool samples from adults and children in Italy.
Clin Infect Dis. 1997 Jan;24(1):12-6 PMID: 8994748
Association of enterotoxigenic Bacteroides fragilis with bacteremia.
Clin Infect Dis. 1996 Dec;23 Suppl 1:S83-6 PMID: 8953112
Enterotoxigenic Bacteroides fragilis.
Clin Infect Dis. 1995 Jun;20 Suppl 2:S142-8 PMID: 7548537
Enterotoxigenic Bacteroides fragilis in Hungary.
Anaerobe. 1997 Apr-Jun;3(2-3):87-9 PMID: 16887568
Isolation of enterotoxigenic Bacteroides fragilis from Bangladeshi children with diarrhea: a controlled study.
J Clin Microbiol. 1994 Apr;32(4):960-3 PMID: 8027350
Association of enterotoxigenic Bacteroides fragilis with diarrheal disease in calves.
J Infect Dis. 1985 Dec;152(6):1344-7 PMID: 3905990
Bacteroides fragilis: a possible cause of acute diarrheal disease in newborn lambs.
Infect Immun. 1984 May;44(2):241-4 PMID: 6538870
Molecular modeling and analysis of fragilysin, the Bacteroides fragilis toxin.
Clin Infect Dis. 1997 Sep;25 Suppl 2:S153-5 PMID: 9310661
Isolation of enterotoxigenic Bacteroides fragilis from humans with diarrhea.
J Clin Microbiol. 1987 Dec;25(12):2330-3 PMID: 3429625
The enterotoxin of Bacteroides fragilis is a metalloprotease.
Infect Immun. 1995 Jan;63(1):175-81 PMID: 7806355
Detection of intestinal and extra-intestinal strains of enterotoxigenic Bacteroides fragilis by the HT-29 cytotoxicity assay.
J Med Microbiol. 1994 Sep;41(3):191-6 PMID: 8064839
Occurrence of Bacteroides fragilis enterotoxin gene-carrying strains in Germany and the United States.
J Clin Microbiol. 2000 May;38(5):1996-7 PMID: 10790139
Bacterial extracellular zinc-containing metalloproteases.
Microbiol Rev. 1993 Dec;57(4):823-37 PMID: 8302217
Human colonic epithelial cells, HT29/C1, treated with crude Bacteroides fragilis enterotoxin dramatically alter their morphology.
Infect Immun. 1992 Feb;60(2):321-7 PMID: 1730463

Article Info

Journal

Journal of clinical microbiology

Abbr.

J Clin Microbiol

ISSN

0095-1137

DOI

10.1128/JCM.41.9.4428-4430.2003

Published

2003-09-00

Pages

4428-30

Language

English

Region

United States

NLM ID

7505564

PMCID

PMC193814

Subset

External Links

PubMed source DOI: 10.1128/JCM.41.9.4428-4430.2003 PMC Full Text View journal details

Analysis Services

Prevalence of fragilysin gene in Bacteroides fragilis isolates from blood and other extraintestinal samples.

Contact

WeChat Official Account