Designing proteins for therapeutic applications.

Current opinion in structural biology ·Vol. 13 ·No. 4 ·2003-08-00 ·Pages 513-8

Lazar GA, Marshall SA, Plecs JJ, Mayo SL, Desjarlais JR

Abstract

Protein design is becoming an increasingly useful tool for optimizing protein drugs and creating novel biotherapeutics. Recent progress includes the engineering of monoclonal antibodies, cytokines, enzymes and viral fusion inhibitors.

MeSH Terms

Animals Antibodies, Monoclonal/pharmacology Antiviral Agents/pharmacology Cytokines/pharmacology Humans Protein Engineering Proteins/pharmacology

Chemicals

Antibodies, Monoclonal Antiviral Agents Cytokines Proteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Lazar Greg A

Xencor, 111 West Lemon Avenue, Monrovia, CA 91016, USA.

Marshall Shannon A

Plecs Joseph J

Mayo Stephen L

Desjarlais John R

Article Info

Journal

Current opinion in structural biology

Abbr.

Curr Opin Struct Biol

ISSN

0959-440X

DOI

10.1016/s0959-440x(03)00104-0

Published

2003-08-00

Pages

513-8

Language

English

Region

England

NLM ID

9107784

Subset

External Links

PubMed source DOI: 10.1016/s0959-440x(03)00104-0 View journal details

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