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PMID: 12927027 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

ADAM metalloproteases and EGFR signalling.

Breast cancer research : BCR ·Vol. 5 ·No. 5 ·2003-00-00 ·Pages 223-4

Gee JM, Knowlden JM

Abstract

暂无摘要

MeSH Terms

Animals Breast Neoplasms/embryology,enzymology,genetics,metabolism CHO Cells Cricetinae ErbB Receptors/genetics,physiology Female Gene Expression Regulation, Neoplastic/genetics,physiology Humans Metalloendopeptidases/genetics,physiology Signal Transduction/genetics,physiology

Chemicals

ErbB Receptors Metalloendopeptidases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Gee Julia M W

Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Wales, UK. gee@cardiff.ac.uk

Knowlden Janice M

References (10)

10 references, click to expand

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Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer.
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The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors.
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Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor.
J Biol Chem. 2002 Aug 2;277(31):27643-50 PMID: 12011069
Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor.
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TACE is required for the activation of the EGFR by TGF-alpha in tumors.
EMBO J. 2003 Mar 3;22(5):1114-24 PMID: 12606576
TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.
EMBO J. 2003 May 15;22(10):2411-21 PMID: 12743035
Expression of ADAM-9 mRNA and protein in human breast cancer.
Int J Cancer. 2003 Jul 20;105(6):754-61 PMID: 12767059
Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.
Am J Pathol. 1999 May;154(5):1489-501 PMID: 10329602
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Article Info

Journal

Breast cancer research : BCR

Abbr.

Breast Cancer Res

ISSN

1465-542X

DOI

10.1186/bcr637

gee@cardiff.ac.uk

Published

2003-00-00

Epub

2003-00-21

Pages

223-4

Language

English

Region

England

NLM ID

100927353

PMCID

PMC314437

Subset

External Links

PubMed source DOI: 10.1186/bcr637 PMC Full Text View journal details

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