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题目:: Molecular cytogenetic approach to the diagnosis of splenic lymphoma: a case report of blastoid mantle cell lymphoma.
作者:: Björck(Erik),Landgren(Ola),Schoumans(Jacqueline),Christensson(Birger),Björkholm(Magnus),MacDonald(Anna Porwit),Nordenskjöld(Magnus)
状态:: 发布时间2003-08-14 , 更新时间 2006-11-15
期刊:: Leuk Lymphoma
摘要:: A 69-year-old woman was admitted to hospital due to abdominal pain. An enlarged spleen was detected and extirpated. Histological examination and FACS analysis could not clearly differentiate between a splenic marginal zone lymphoma and a mantle cell lymphoma. Using molecular cytogenetic techniques, a complex karyotype including a translocation between chromosome 11 and 14 consistent with a triple fusion between heavy chain immunoglobulin locus (IgH) and cyclin D1 (CCND1) was demonstrated. Overexpression of cyclin D1 was detected by immunostaining. Thus the diagnosis of a splenic blastoid mantle cell lymphoma could be established. In this report, various aspects of differential diagnosis of splenic lymphomas are discussed.
语言:: eng
DOI:: 10.1080/1042819031000077061

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