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题目:: Natural killer T cells in patients with prostatic carcinoma.
作者:: Schwemmer(B)
状态:: 发布时间2003-07-31 , 更新时间 2006-10-30
期刊:: Urol Int
摘要:: Recent interest has focused on natural killer T (NKT) cells as effector cells in a possible new form of immunotherapy. NKT cells express T cell and natural killer cell receptors. They are CD1d-dependent and can be stimulated by alpha-galactosylceramide. We have studied peripheral blood levels of NKT cells simultaneously with CD8+ cells and natural killer cells in 54 patients with prostatic carcinoma. Levels of NKT cells in patients with androgen withdrawal and stable PSA levels were 211.8 +/- 138.4 cells/microl and in patients with rising PSA levels were 27.0 +/- 22.1 cells/microl. A similar but less pronounced difference in CD8+ cells between these groups was found (656.4 vs. 212.0 cells/microl). Comparing all 54 patients studied, a positive correlation was found between the levels of NKT cells and CD8+ cells (r = 0.83). Our results suggest an important and regulatory role of NKT cells in patients with prostatic carcinoma.
语言:: eng
DOI:

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