Phosphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor clinical outcome.

Acute Disease Adolescent Adult Aged Blotting, Western DNA-Binding Proteins/metabolism Female Forkhead Box Protein O1 Forkhead Transcription Factors Glycogen Synthase Kinase 3/metabolism Glycogen Synthase Kinase 3 beta Humans Leukemia, Myeloid/metabolism,mortality Male Middle Aged Multivariate Analysis PTEN Phosphohydrolase Phosphoric Monoester Hydrolases/analysis Phosphorylation Prognosis Protein Serine-Threonine Kinases Proto-Oncogene Proteins/metabolism Proto-Oncogene Proteins c-akt Statistics, Nonparametric Transcription Factors/metabolism Tumor Suppressor Proteins/analysis

DNA-Binding Proteins FOXO1 protein, human Forkhead Box Protein O1 Forkhead Transcription Factors Proto-Oncogene Proteins Transcription Factors Tumor Suppressor Proteins AKT1 protein, human GSK3B protein, human Glycogen Synthase Kinase 3 beta Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt Glycogen Synthase Kinase 3 Phosphoric Monoester Hydrolases PTEN Phosphohydrolase PTEN protein, human