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PMID: 12808468 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice.

Nature ·Vol. 424 ·No. 6944 ·2003-07-03 ·Pages 76-81

Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG, Yau KW

Abstract

In the mammalian retina, besides the conventional rod-cone system, a melanopsin-associated photoreceptive system exists that conveys photic information for accessory visual functions such as pupillary light reflex and circadian photo-entrainment. On ablation of the melanopsin gene, retinal ganglion cells that normally express melanopsin are no longer intrinsically photosensitive. Furthermore, pupil reflex, light-induced phase delays of the circadian clock and period lengthening of the circadian rhythm in constant light are all partially impaired. Here, we investigated whether additional photoreceptive systems participate in these responses. Using mice lacking rods and cones, we measured the action spectrum for phase-shifting the circadian rhythm of locomotor behaviour. This spectrum matches that for the pupillary light reflex in mice of the same genotype, and that for the intrinsic photosensitivity of the melanopsin-expressing retinal ganglion cells. We have also generated mice lacking melanopsin coupled with disabled rod and cone phototransduction mechanisms. These animals have an intact retina but fail to show any significant pupil reflex, to entrain to light/dark cycles, and to show any masking response to light. Thus, the rod-cone and melanopsin systems together seem to provide all of the photic input for these accessory visual functions.

MeSH Terms
Animals Circadian Rhythm/physiology Cyclic Nucleotide-Gated Cation Channels Darkness Female Gene Deletion Ion Channels/genetics,metabolism Light Male Mice Mice, Inbred C3H Mice, Knockout Motor Activity/physiology Reflex, Pupillary/physiology Retinal Cone Photoreceptor Cells/physiology Retinal Ganglion Cells/metabolism Retinal Rod Photoreceptor Cells/physiology Rod Opsins/genetics,metabolism Vision, Ocular/physiology Visual Perception/physiology
Chemicals
Cyclic Nucleotide-Gated Cation Channels Ion Channels Rod Opsins melanopsin
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Hattar S
Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Lucas R J
Mrosovsky N
Thompson S
Douglas R H
Hankins M W
Lem J
Biel M
Hofmann F
Foster R G
Yau K-W
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
Published
2003-07-03
Epub
2003-00-15
Pages
76-81
Language
English
Region
England
NLM ID
0410462
PMCID
PMC2885907
Subset
IM
Grants
NEI NIH HHS · R01 EY006837 · United States
NEI NIH HHS · R01 EY014596 · United States
NEI NIH HHS · R37 EY006837-15S1 · United States
NEI NIH HHS · R01 EY014596-01 · United States
NEI NIH HHS · R37 EY006837 · United States
NEI NIH HHS · R37 EY006837-13 · United States
NEI NIH HHS · R37 EY006837-14 · United States
NEI NIH HHS · R01 EY006837-16A1 · United States
NEI NIH HHS · R37 EY006837-15 · United States
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