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PMID: 1279978 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Elevated vascular cell adhesion molecule-1 in AIDS encephalitis induced by simian immunodeficiency virus.

The American journal of pathology ·Vol. 141 ·No. 5 ·1992-11-00 ·Pages 1021-30

Sasseville VG, Newman WA, Lackner AA, Smith MO, Lausen NC, Beall D, Ringler DJ

Abstract

AIDS encephalitis is a common sequela to HIV-1 infection in humans and simian immunodeficiency virus (SIVmac) infection in macaques. Although lentiviral-infected macrophages comprise parenchymal inflammatory infiltrates in affected brain tissue, the mechanisms responsible for leukocyte trafficking to the central nervous system in AIDS are unknown. In this study, we investigated the expression of various endothelial-derived leukocyte adhesion proteins in SIVmac-induced AIDS encephalitis. Encephalitic brains from SIVmac-infected macaques, but not uninflamed brains from other SIVmac-infected animals, were found to express abundant vascular cell adhesion molecule-1 (VCAM-1) protein on the majority of arteriolar, venular, and capillary endothelial cells. Soluble VCAM-1 concentrations in cerebrospinal fluid (CSF) from encephalitic animals were increased approximately 20-fold above those from animals without AIDS encephalitis. Expression of other endothelial-related adhesion molecules, including E-selectin, P-selectin, and intercellular adhesion molecule-1 (ICAM-1), was not uniformly associated with AIDS encephalitis. Thus, the presence of VCAM-1 in both brain and CSF was uniformly associated with SIVmac-induced disease of the central nervous system, and this expression may, at least in part, influence monocyte and lymphocyte recruitment to the central nervous system during the development of AIDS encephalitis. Moreover, measurement of soluble VCAM-1 in CSF may assist in the clinical assessment of animals or people with AIDS.

MeSH Terms
AIDS Dementia Complex/etiology,metabolism Animals Brain/blood supply,microbiology,pathology Brain Chemistry Cell Adhesion Molecules/analysis,cerebrospinal fluid,physiology Endothelium, Vascular/chemistry,pathology Enzyme-Linked Immunosorbent Assay Ependyma/chemistry,pathology Immunohistochemistry Intercellular Adhesion Molecule-1 Macaca fascicularis Macaca mulatta Macaca nemestrina P-Selectin Platelet Membrane Glycoproteins/analysis Simian Acquired Immunodeficiency Syndrome/complications Simian Immunodeficiency Virus/isolation & purification,physiology Vascular Cell Adhesion Molecule-1
Chemicals
Cell Adhesion Molecules P-Selectin Platelet Membrane Glycoproteins Vascular Cell Adhesion Molecule-1 Intercellular Adhesion Molecule-1
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Sasseville V G
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772-9102.
Newman W A
Lackner A A
Smith M O
Lausen N C
Beall D
Ringler D J
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1992-11-00
Pages
1021-30
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1886675
Subset
IM
Grants
NIAID NIH HHS · AI 25644 · United States
NIAID NIH HHS · AI 29855 · United States
NCRR NIH HHS · RR 00168 · United States
External Links
PubMed source PMC Full Text View journal details
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