Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model.

Nutritional neuroscience ·Vol. 6 ·No. 3 ·2003-06-00 ·Pages 153-62

Joseph JA, Denisova NA, Arendash G, Gordon M, Diamond D, Shukitt-Hale B, Morgan D

Abstract

Previously, we showed that blueberry (BB) supplementation reversed the deleterious effects of aging on motor behavior and neuronal signaling in senescent rodents. We now report that BB-fed (from 4 months of age) APP + PS1 transgenic mice showed no deficits in Y-maze performance (at 12 months of age) with no alterations in amyloid beta burden. It appeared that the protective mechanisms are derived from BB-induced enhancement of memory-associated neuronal signaling (e.g. extracellular signal-regulated kinase) and alterations in neutral sphingomyelin-specific phospholipase C activity. Thus, our data indicate for the first time that it may be possible to overcome genetic predispositions to Alzheimer disease through diet.

MeSH Terms

Alzheimer Disease/drug therapy,genetics,physiopathology Amyloid beta-Peptides/analysis Amyloid beta-Protein Precursor/genetics Animals Behavior, Animal Blueberry Plants Brain/enzymology Diet Disease Models, Animal Fruit GTP Phosphohydrolases/metabolism Genetic Predisposition to Disease Membrane Proteins/genetics Memory Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Mitogen-Activated Protein Kinases/metabolism Neurons/physiology Phytotherapy Plant Extracts/therapeutic use Presenilin-1 Protein Kinase C/metabolism Protein Kinase C-alpha Signal Transduction Sphingomyelins/metabolism Type C Phospholipases/metabolism

Chemicals

Amyloid beta-Peptides Amyloid beta-Protein Precursor Membrane Proteins Plant Extracts Presenilin-1 Sphingomyelins Prkca protein, mouse Protein Kinase C Protein Kinase C-alpha Mitogen-Activated Protein Kinases Type C Phospholipases GTP Phosphohydrolases

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Joseph J A

USDA-HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA. james.joseph@tufts.edu

Denisova N A

Arendash G

Gordon M

Diamond D

Shukitt-Hale B

Morgan D

Article Info

Journal

Nutritional neuroscience

Abbr.

Nutr Neurosci

ISSN

1028-415X

DOI

10.1080/1028415031000111282

james.joseph@tufts.edu

Published

2003-06-00

Pages

153-62

Language

English

Region

England

NLM ID

100892202

Subset

External Links

PubMed source DOI: 10.1080/1028415031000111282 View journal details

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Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model.

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