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PMID: 12792021 Published · ppublish English Journal Article

Evidence for neurogenesis in the adult mammalian substantia nigra.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 100 ·No. 13 ·2003-06-24 ·Pages 7925-30

Zhao M, Momma S, Delfani K, Carlen M, Cassidy RM, Johansson CB, Brismar H, Shupliakov O, Frisen J, Janson AM

Abstract

New neurons are generated from stem cells in a few regions of the adult mammalian brain. Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain and show that the rate of neurogenesis is increased after a lesion. The number of new neurons generated under physiological conditions in substantia nigra pars compacta was found to be several orders of magnitude smaller than in the granular cell layer of the dentate gyrus of the hippocampus. However, if the rate of neuronal turnover is constant, the entire population of dopaminergic neurons in substantia nigra could be replaced during the lifespan of a mouse. These data indicate that neurogenesis in the adult brain is more widespread than previously thought and may have implications for our understanding of the pathogenesis and treatment of neurodegenerative disorders such as Parkinson's disease.

MeSH Terms
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology Animals Antimetabolites/pharmacology Apoptosis Bromodeoxyuridine/pharmacology Dopamine/metabolism Dopamine Agents/pharmacology Hippocampus/pathology Humans Male Mice Mice, Inbred C57BL Microscopy, Fluorescence Neurons/metabolism,pathology Parkinson Disease/pathology Stem Cells/metabolism Substantia Nigra/anatomy & histology,metabolism,pathology Synapses Time Factors
Chemicals
Antimetabolites Dopamine Agents 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Bromodeoxyuridine Dopamine
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Zhao Ming
Departments of Neuroscience, Cell and Molecular Biology, Medical Nobel Institute, and Woman and Child Health, Karolinska Institute, SE-171 77 Stockholm, Sweden.
Momma Stefan
Delfani Kioumars
Carlen Marie
Cassidy Robert M
Johansson Clas B
Brismar Hjalmar
Shupliakov Oleg
Frisen Jonas
Janson Ann Marie
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.1131955100
Published
2003-06-24
Epub
2003-00-05
Pages
7925-30
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC164689
Subset
IM
Corrections
CommentIn
PMID: 12810949
CommentIn
PMID: 15210991
External Links
PubMed source DOI: 10.1073/pnas.1131955100 PMC Full Text View journal details
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