| GeneLibs

题目:: B cells as effectors.
作者:: McHeyzer-Williams(Michael G)
状态:: 发布时间2003-06-05 , 更新时间 2005-11-16
期刊:: Curr Opin Immunol
摘要:: B cells act as immune effectors, primarily through antigen-specific clonal expansion and plasma-cell differentiation. B1 (CD5(+)) B cells and marginal zone B cells dominate T-cell independent humoral responses under the molecular control of activated dendritic cells. Helper T cell-regulated B-cell responses draw on follicular B cells as precursors and rely on qualitatively different patterns of immune synapse formation to regulate B-cell fate. These activities culminate in the germinal center reaction, during which somatic hypermutation and antigen-driven selection produce and preserve high-affinity plasma cells with extended longevity and memory B cells as the sensitized precursors for antigen recall.
语言:: eng
DOI:

文献库文献相关信息