Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK.

Amino Acid Sequence Catalytic Domain Cell Line Cell Movement Cells, Cultured DNA, Complementary/metabolism Endothelin-1/metabolism Endothelins/metabolism Enzyme Activation Genes, Dominant Glutathione Transferase/metabolism Guanine Nucleotide Exchange Factors/chemistry,physiology Humans JNK Mitogen-Activated Protein Kinases MAP Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinases/metabolism Mitogen-Activated Protein Kinases/metabolism Models, Biological Molecular Sequence Data Mutation Phosphorylation Proline/chemistry Protein Binding Proteins/metabolism Receptor, Endothelin A Receptors, Endothelin/metabolism Recombinant Fusion Proteins/metabolism Recombinant Proteins/metabolism Sequence Homology, Amino Acid Signal Transduction Time Factors Transfection Tyrosine/metabolism cdc42 GTP-Binding Protein/metabolism rac1 GTP-Binding Protein/metabolism rho GTP-Binding Proteins/metabolism rhoA GTP-Binding Protein/metabolism src-Family Kinases/physiology

DNA, Complementary Endothelin-1 Endothelins FGD1 protein, human FGD1-related Cdc42-GEF protein, human Guanine Nucleotide Exchange Factors Proteins Receptor, Endothelin A Receptors, Endothelin Recombinant Fusion Proteins Recombinant Proteins Tyrosine Proline Glutathione Transferase src-Family Kinases JNK Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases MAP Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinases cdc42 GTP-Binding Protein rac1 GTP-Binding Protein rho GTP-Binding Proteins rhoA GTP-Binding Protein