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PMID: 12771123 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Caveolae/raft-dependent endocytosis.

The Journal of cell biology ·Vol. 161 ·No. 4 ·2003-05-26 ·Pages 673-7

Nabi IR, Le PU

Abstract

Although caveolae are well-characterized subdomains of glycolipid rafts, their distinctive morphology and association with caveolins has led to their internalization being considered different from that of rafts. In this review, we propose that caveolae and rafts are internalized via a common pathway, caveolae/raft-dependent endocytosis, defined by its clathrin independence, dynamin dependence, and sensitivity to cholesterol depletion. The regulatory role of caveolin-1 and ligand sorting in this complex endocytic pathway are specifically addressed.

MeSH Terms
Animals Caveolae/metabolism Caveolin 1 Caveolins/metabolism Cholesterol/metabolism Cytoplasmic Vesicles/metabolism Endocytosis Membrane Microdomains/metabolism
Chemicals
Caveolin 1 Caveolins Cholesterol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nabi Ivan R
Département de Pathologie et Biologie Cellulaire, Université de Montréal, C.P. 6128, Succursale A, Montréal, Québec, Canada H3C 3J7. ivan.robert.nabi@umontreal.ca
Le Phuong U
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200302028
Email
ivan.robert.nabi@umontreal.ca
Published
2003-05-26
Pages
673-7
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2199359
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.200302028 PMC Full Text View journal details
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