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PMID: 1276835 Published · ppublish English Journal Article

Enhanced drug metabolism in cigarette smokers.

British medical journal ·Vol. 2 ·No. 6028 ·1976-07-17 ·Pages 147-9

Hart P, Farrell GC, Cooksley WG, Powell LW

Abstract

The effect of cigarette smoking on salivary antipyrine disappearance rate, and as an index of hepatic drug metabolism, was studied in 42 healthy subjects. Antipyrine half life was significantly shorter in smokers compared with non-smokers. To determine whether this difference was due solely to tobacco consumption eight subjects were restudied two months after they stopped smoking. The mean antipyrine disappearance rate in this group increased by 23% in contrast to that of a control group, which did not alter. Cigarette smoking contributes to the considerable variation in interindividual rates of drug metabolism.

MeSH Terms
Adolescent Adult Antipyrine/blood,metabolism Female Half-Life Humans Liver/metabolism Male Middle Aged Saliva/analysis Smoking
Chemicals
Antipyrine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hart P
Farrell G C
Cooksley W G
Powell L W
References (22)
22 references, click to expand
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Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.2.6028.147
Published
1976-07-17
Pages
147-9
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1687451
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.2.6028.147 PMC Full Text
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