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PMID: 12764080 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The underpinnings of the BOLD functional magnetic resonance imaging signal.

Logothetis NK

Abstract

暂无摘要

MeSH Terms
Animals Brain/blood supply,physiology Carbon Dioxide/blood Cerebrovascular Circulation/physiology Echo-Planar Imaging/methods Humans Magnetic Resonance Imaging/methods Magnetic Resonance Spectroscopy/methods Oxygen/blood
Chemicals
Carbon Dioxide Oxygen
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Logothetis Nikos K
Max Planck Institute for Biological Cybernetics, 72076 Tuebingen, Germany. nikos.logothetis@tuebingen.mpg.de
References (112)
112 references, click to expand
  1. Spatial attention affects brain activity in human primary visual cortex.
    Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3314-9 PMID: 10077681
  2. Simultaneous recording of evoked potentials and T2*-weighted MR images during somatosensory stimulation of rat.
    Magn Reson Med. 1999 Mar;41(3):469-73 PMID: 10204868
  3. Evidence of a cerebrovascular postarteriole windkessel with delayed compliance.
    J Cereb Blood Flow Metab. 1999 Jun;19(6):679-89 PMID: 10366199
  4. Interdependence of multiple theta generators in the hippocampus: a partial coherence analysis.
    J Neurosci. 1999 Jul 15;19(14):6200-12 PMID: 10407056
  5. Sensing and deciding in the somatosensory system.
    Curr Opin Neurobiol. 1999 Aug;9(4):487-93 PMID: 10448157
  6. Functional imaging of the monkey brain.
    Nat Neurosci. 1999 Jun;2(6):555-62 PMID: 10448221
  7. Visual stimulation elicits locked and induced gamma oscillations in monkey intracortical- and EEG-potentials, but not in human EEG.
    Exp Brain Res. 1999 Nov;129(2):247-59 PMID: 10591899
  8. Temporal coupling between neuronal activity and blood flow in rat cerebellar cortex as indicated by field potential analysis.
    J Physiol. 2000 Feb 15;523 Pt 1:235-46 PMID: 10673558
  9. Differential processing of objects under various viewing conditions in the human lateral occipital complex.
    Neuron. 1999 Sep;24(1):187-203 PMID: 10677037
  10. Mechanisms of visual attention in the human cortex.
    Annu Rev Neurosci. 2000;23:315-41 PMID: 10845067
  11. Spikes versus BOLD: what does neuroimaging tell us about neuronal activity?
    Nat Neurosci. 2000 Jul;3(7):631-3 PMID: 10862687
  12. A direct quantitative relationship between the functional properties of human and macaque V5.
    Nat Neurosci. 2000 Jul;3(7):716-23 PMID: 10862705
  13. Intracellular features predicted by extracellular recordings in the hippocampus in vivo.
    J Neurophysiol. 2000 Jul;84(1):390-400 PMID: 10899213
  14. Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements.
    J Neurophysiol. 2000 Jul;84(1):401-14 PMID: 10899214
  15. Activity in primary visual cortex predicts performance in a visual detection task.
    Nat Neurosci. 2000 Sep;3(9):940-5 PMID: 10966626
  16. Category-specific visual responses of single neurons in the human medial temporal lobe.
    Nat Neurosci. 2000 Sep;3(9):946-53 PMID: 10966627
  17. An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds.
    Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11026-31 PMID: 11005873
  18. Neuronal activity in human primary visual cortex correlates with perception during binocular rivalry.
    Nat Neurosci. 2000 Nov;3(11):1153-9 PMID: 11036274
  19. Imagery neurons in the human brain.
    Nature. 2000 Nov 16;408(6810):357-61 PMID: 11099042
  20. Interocular rivalry revealed in the human cortical blind-spot representation.
    Nature. 2001 May 10;411(6834):195-9 PMID: 11346796
  21. Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data.
    Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6859-64 PMID: 11381119
  22. Neurophysiological investigation of the basis of the fMRI signal.
    Nature. 2001 Jul 12;412(6843):150-7 PMID: 11449264
  23. Representation of perceived object shape by the human lateral occipital complex.
    Science. 2001 Aug 24;293(5534):1506-9 PMID: 11520991
  24. Motion processing in the macaque: revisited with functional magnetic resonance imaging.
    J Neurosci. 2001 Nov 1;21(21):8594-601 PMID: 11606647
  25. Visual competition.
    Nat Rev Neurosci. 2002 Jan;3(1):13-21 PMID: 11823801
  26. Theta oscillations in the hippocampus.
    Neuron. 2002 Jan 31;33(3):325-40 PMID: 11832222
  27. What does fMRI tell us about neuronal activity?
    Nat Rev Neurosci. 2002 Feb;3(2):142-51 PMID: 11836522
  28. Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI.
    Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10765-70 PMID: 12134056
  29. Total neuroenergetics support localized brain activity: implications for the interpretation of fMRI.
    Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10771-6 PMID: 12134057
  30. The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal.
    Philos Trans R Soc Lond B Biol Sci. 2002 Aug 29;357(1424):1003-37 PMID: 12217171
  31. Discharge patterns and functional organization of mammalian retina.
    J Neurophysiol. 1953 Jan;16(1):37-68 PMID: 13035466
  32. Modality and topographic properties of single neurons of cat's somatic sensory cortex.
    J Neurophysiol. 1957 Jul;20(4):408-34 PMID: 13439410
  33. Specific impedance of rabbit cerebral cortex.
    Exp Neurol. 1963 Feb;7:144-52 PMID: 13990734
  34. DELAYED DEPOLARIZATION AND THE REPETITIVE RESPONSE TO INTRACELLULAR STIMULATION OF MAMMALIAN MOTONEURONES.
    J Physiol. 1963 Oct;168:890-910 PMID: 14072864
  35. SLOW CHANGES IN THE ELECTROCORTICOGRAM AND THE ACTIVITY OF CORTICAL NEURONS.
    Electroencephalogr Clin Neurophysiol. 1964 Nov;17:520-3 PMID: 14229852
  36. ELECTRICAL ACTIVITY OF THE BRAIN: SLOW WAVES AND NEURONAL ACTIVITY.
    Isr J Med Sci. 1965 Jan;1:104-17 PMID: 14256941
  37. Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.
    J Physiol. 1962 Jan;160:106-54 PMID: 14449617
  38. Electrophysiology of a dendritic neuron model.
    Biophys J. 1962 Mar;2(2 Pt 2):145-67 PMID: 14490040
  39. The reflex activity of mammalian small-nerve fibres.
    J Physiol. 1951 Dec 28;115(4):456-69 PMID: 14898522
  40. Changes in the distributed temporal response properties of SI cortical neurons reflect improvements in performance on a temporally based tactile discrimination task.
    J Neurophysiol. 1992 May;67(5):1071-91 PMID: 1597698
  41. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
    Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5675-9 PMID: 1608978
  42. Time course EPI of human brain function during task activation.
    Magn Reson Med. 1992 Jun;25(2):390-7 PMID: 1614324
  43. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.
    Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5951-5 PMID: 1631079
  44. The impulses produced by sensory nerve-endings: Part II. The response of a Single End-Organ.
    J Physiol. 1926 Apr 23;61(2):151-71 PMID: 16993780
  45. Cortical connections of the caudal subdivision of the dorsolateral area (V4) in monkeys.
    J Comp Neurol. 1991 Apr 15;306(3):495-520 PMID: 1713928
  46. Encoding of olfactory information with oscillating neural assemblies.
    Science. 1994 Sep 23;265(5180):1872-5 PMID: 17797226
  47. Echo-planar time course MRI of cat brain oxygenation changes.
    Magn Reson Med. 1991 Nov;22(1):159-66 PMID: 1798390
  48. Susceptibility contrast imaging of cerebral blood volume: human experience.
    Magn Reson Med. 1991 Dec;22(2):293-9; discussion 300-3 PMID: 1812360
  49. Higher olfactory processes: perceptual learning and memory.
    Curr Opin Neurobiol. 1991 Aug;1(2):209-14 PMID: 1821183
  50. Distributed hierarchical processing in the primate cerebral cortex.
    Cereb Cortex. 1991 Jan-Feb;1(1):1-47 PMID: 1822724
  51. Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons.
    Science. 1991 Jan 25;251(4992):432-5 PMID: 1824881
  52. Functional mapping of the human visual cortex by magnetic resonance imaging.
    Science. 1991 Nov 1;254(5032):716-9 PMID: 1948051
  53. Action potential of the motoneurons of the hypoglossus nucleus.
    J Cell Comp Physiol. 1947 Jun;29(3):207-87 PMID: 20245515
  54. Frequency discrimination in the sense of flutter: psychophysical measurements correlated with postcentral events in behaving monkeys.
    J Neurosci. 1990 Sep;10(9):3032-44 PMID: 2118947
  55. Brain magnetic resonance imaging with contrast dependent on blood oxygenation.
    Proc Natl Acad Sci U S A. 1990 Dec;87(24):9868-72 PMID: 2124706
  56. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields.
    Magn Reson Med. 1990 Apr;14(1):68-78 PMID: 2161986
  57. Oscillatory activity of single units in a somatosensory cortex of an awake monkey and their possible role in texture analysis.
    Proc Natl Acad Sci U S A. 1990 Nov;87(22):8935-9 PMID: 2247469
  58. Magnetic resonance imaging of blood vessels at high fields: in vivo and in vitro measurements and image simulation.
    Magn Reson Med. 1990 Oct;16(1):9-18 PMID: 2255240
  59. Ionic mechanisms underlying the firing properties of rat neonatal motoneurons studied in vitro.
    Neuroscience. 1986 Nov;19(3):669-83 PMID: 2432443
  60. Nucleus basalis and thalamic control of neocortical activity in the freely moving rat.
    J Neurosci. 1988 Nov;8(11):4007-26 PMID: 3183710
  61. Nonoxidative glucose consumption during focal physiologic neural activity.
    Science. 1988 Jul 22;241(4864):462-4 PMID: 3260686
  62. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.
    Proc Natl Acad Sci U S A. 1986 Feb;83(4):1140-4 PMID: 3485282
  63. Visual properties of neurons in area V4 of the macaque: sensitivity to stimulus form.
    J Neurophysiol. 1987 Mar;57(3):835-68 PMID: 3559704
  64. Properties of the evoked potential generators: current source-density analysis of visually evoked potentials in the cat cortex.
    Int J Neurosci. 1987 Mar;33(1-2):33-59 PMID: 3610492
  65. Cortical connections of visual area MT in the macaque.
    J Comp Neurol. 1986 Jun 8;248(2):190-222 PMID: 3722458
  66. Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena.
    Physiol Rev. 1985 Jan;65(1):37-100 PMID: 3880898
  67. On the number of neurons in the dentate gyrus of the rat.
    Brain Res. 1985 Jul 8;338(1):144-50 PMID: 3896391
  68. Properties of pyramidal tract neuron system within a functionally defined subregion of primate motor cortex.
    J Neurophysiol. 1978 Jan;41(1):216-43 PMID: 413887
  69. The relationship between neuron activity and cortical steady potentials.
    Electroencephalogr Clin Neurophysiol. 1967 Feb;22(2):159-66 PMID: 4163686
  70. The physiological interpretation of amplitude histograms of the EEG.
    Electroencephalogr Clin Neurophysiol. 1969 Sep;27(7):703-4 PMID: 4187403
  71. Field potentials in the alligator cerebellum and theory of their relationship to Purkinje cell dendritic spikes.
    J Neurophysiol. 1971 Jul;34(4):509-31 PMID: 4329777
  72. Sampling properties of microelectrodes assessed in the cat's retina.
    J Neurophysiol. 1973 Nov;36(6):1071-9 PMID: 4761721
  73. The genesis of the EEG.
    Int Rev Neurobiol. 1971 Jul;15:227-72 PMID: 4949975
  74. Amplitudes of background fast activity characteristic of specific brain sites.
    J Neurophysiol. 1970 Jan;33(1):148-59 PMID: 5411510
  75. Correlation of cell size with amplitude of background fast activity in specific brain nuclei.
    J Neurophysiol. 1970 Jan;33(1):160-71 PMID: 5411511
  76. Extracellular microelectrode sampling bias.
    Exp Neurol. 1970 Nov;29(2):366-81 PMID: 5504476
  77. The effects of graded hypoxia upon transient cerebral blood flow and oxygen consumption.
    Neurology. 1968 Feb;18(2):127-33 PMID: 5688754
  78. Interpretation of the vertex short-latency acoustic response: a study of single neurons in the brain stem.
    Brain Res. 1977 Dec 2;137(2):291-303 PMID: 589456
  79. Interaction between spinal motoneurons of the cat.
    J Neurophysiol. 1966 Mar;29(2):275-87 PMID: 5927462
  80. Electrical impedance in the subicular area of rats during paradoxical sleep.
    Exp Neurol. 1966 Dec;16(4):416-37 PMID: 5957203
  81. Afterpotentials and transduction properties in different types of central neurones.
    Arch Ital Biol. 1984 Mar;122(1):17-30 PMID: 6087759
  82. The connections of the middle temporal visual area (MT) and their relationship to a cortical hierarchy in the macaque monkey.
    J Neurosci. 1983 Dec;3(12):2563-86 PMID: 6655500
  83. Averaged multiple unit activity as an estimate of phasic changes in local neuronal activity: effects of volume-conducted potentials.
    J Neurosci Methods. 1980 Apr;2(2):203-17 PMID: 6771471
  84. The calcium component of the action potential in spinal motoneurones of the rat.
    J Physiol. 1983 Feb;335:89-100 PMID: 6875900
  85. Neuronal activity during the sleep-waking cycle.
    Prog Neurobiol. 1976;6(3-4):155-376 PMID: 6996
  86. A laminar analysis of the number of neurons, glia, and synapses in the adult cortex (area 17) of adult macaque monkeys.
    J Comp Neurol. 1982 Sep 20;210(3):278-90 PMID: 7142443
  87. Similarity in number of neurons through the depth of the cortex in the binocular and monocular parts of area 17 of the monkey.
    Brain Res. 1981 Jul 20;216(2):409-13 PMID: 7248781
  88. Temporal structure in spatially organized neuronal ensembles: a role for interneuronal networks.
    Curr Opin Neurobiol. 1995 Aug;5(4):504-10 PMID: 7488853
  89. The intravascular contribution to fMRI signal change: Monte Carlo modeling and diffusion-weighted studies in vivo.
    Magn Reson Med. 1995 Jul;34(1):4-10 PMID: 7674897
  90. Electrophysiological properties of guinea pig trigeminal motoneurons recorded in vitro.
    J Neurophysiol. 1994 Jan;71(1):129-45 PMID: 7908952
  91. Quantitative analysis of GABA-like-immunoreactive and parvalbumin-containing neurons in the CA1 region of the rat hippocampus using a stereological method, the disector.
    Exp Brain Res. 1994;99(2):267-76 PMID: 7925807
  92. Theory of current source-density analysis and determination of conductivity tensor for anuran cerebellum.
    J Neurophysiol. 1975 Mar;38(2):356-68 PMID: 805215
  93. Thalamocortical oscillations in the sleeping and aroused brain.
    Science. 1993 Oct 29;262(5134):679-85 PMID: 8235588
  94. Ionic mechanisms underlying the depolarizing and hyperpolarizing afterpotentials of single spike in guinea-pig cingulate cortical neurons.
    Neuroscience. 1993 Jul;55(1):129-38 PMID: 8350984
  95. Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man.
    Magn Reson Med. 1996 Feb;35(2):143-8 PMID: 8622575
  96. Topography and intracranial sources of somatosensory evoked potentials in the monkey. I. Early components.
    Electroencephalogr Clin Neurophysiol. 1979 Feb;46(2):155-72 PMID: 86423
  97. Tetrodes markedly improve the reliability and yield of multiple single-unit isolation from multi-unit recordings in cat striate cortex.
    J Neurosci Methods. 1995 Dec;63(1-2):43-54 PMID: 8788047
  98. Chattering cells: superficial pyramidal neurons contributing to the generation of synchronous oscillations in the visual cortex.
    Science. 1996 Oct 4;274(5284):109-13 PMID: 8810245
  99. A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation.
    J Cereb Blood Flow Metab. 1997 Jan;17(1):64-72 PMID: 8978388
  100. Neural mechanisms of spatial selective attention in areas V1, V2, and V4 of macaque visual cortex.
    J Neurophysiol. 1997 Jan;77(1):24-42 PMID: 9120566
  101. Single neuron activity in human hippocampus and amygdala during recognition of faces and objects.
    Neuron. 1997 May;18(5):753-65 PMID: 9182800
  102. Comparison of blood oxygenation and cerebral blood flow effects in fMRI: estimation of relative oxygen consumption change.
    Magn Reson Med. 1997 Jul;38(1):59-65 PMID: 9211380
  103. Role of calcium conductances on spike afterpotentials in rat trigeminal motoneurons.
    J Neurophysiol. 1997 Jun;77(6):3273-83 PMID: 9212274
  104. Cellular-synaptic generation of sleep spindles, spike-and-wave discharges, and evoked thalamocortical responses in the neocortex of the rat.
    J Neurosci. 1997 Sep 1;17(17):6783-97 PMID: 9254689
  105. Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging.
    Nat Med. 1998 Feb;4(2):159-67 PMID: 9461188
  106. Dynamics of blood flow and oxygenation changes during brain activation: the balloon model.
    Magn Reson Med. 1998 Jun;39(6):855-64 PMID: 9621908
  107. On the characteristics of functional magnetic resonance imaging of the brain.
    Annu Rev Biophys Biomol Struct. 1998;27:447-74 PMID: 9646874
  108. Theta oscillations in somata and dendrites of hippocampal pyramidal cells in vivo: activity-dependent phase-precession of action potentials.
    Hippocampus. 1998;8(3):244-61 PMID: 9662139
  109. A model for the regulation of cerebral oxygen delivery.
    J Appl Physiol (1985). 1998 Aug;85(2):554-64 PMID: 9688733
  110. Mechanisms of directed attention in the human extrastriate cortex as revealed by functional MRI.
    Science. 1998 Oct 2;282(5386):108-11 PMID: 9756472
  111. Modification of activity-dependent increases of cerebral blood flow by excitatory synaptic activity and spikes in rat cerebellar cortex.
    J Physiol. 1998 Oct 15;512 ( Pt 2):555-66 PMID: 9763643
  112. Effects of attention on orientation-tuning functions of single neurons in macaque cortical area V4.
    J Neurosci. 1999 Jan 1;19(1):431-41 PMID: 9870971
Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
Published
2003-05-15
Pages
3963-71
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6741096
Subset
IM
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