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PMID: 12756555 Published · ppublish English Journal Article

A Plasmodium homologue of cochaperone p23 and its differential expression during the replicative cycle of the malaria parasite.

Parasitology research ·Vol. 90 ·No. 2 ·2003-06-00 ·Pages 166-70

Wiser MF

Abstract

The complete gene sequence of a major phosphoprotein from the malaria parasite reveals that it is a homologue to cochaperone p23. This p23 homologue is highly conserved between Plasmodium falciparum and other malaria parasites and exhibits 44% sequence identity with the Schizosaccharomyces pombe p23 homologue. The Plasmodium p23 is a relatively abundant cytoplasmic protein with a molecular mass of 34-36 kDa depending on species. Expression of this 34 kDa protein and its mRNA commences in the early ring stage and continues throughout the trophozoite stage. At the beginning of schizogony there is a decrease in the transcription and translation rates and a decline in the amount of the 34 kDa protein. The exact role of the 34 kDa phosphoprotein in parasite replication and differentiation is not known, but the Plasmodium p23 homologue may play a role in parasite proliferation and differentiation through its interactions with protein kinases and other chaperones.

MeSH Terms
Animals Base Sequence DNA Replication Fluorescent Antibody Technique Life Cycle Stages/genetics Molecular Chaperones/metabolism Phosphoproteins/metabolism Plasmodium/genetics,growth & development,metabolism,physiology Protozoan Proteins/metabolism Schizosaccharomyces pombe Proteins Sequence Alignment
Chemicals
Molecular Chaperones Phosphoproteins Protozoan Proteins Schizosaccharomyces pombe Proteins wos2 protein, S pombe
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Wiser Mark F
Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, SL17, New Orleans, LA 70112, USA. wiser@tulane.edu
References (26)
26 references, click to expand
  1. Identification, cloning, and mutational analysis of the casein kinase 1 cDNA of the malaria parasite, Plasmodium falciparum. Stage-specific expression of the gene.
    J Biol Chem. 1997 Oct 17;272(42):26132-8 PMID: 9334178
  2. Analysis of expressed sequence tags from Plasmodium falciparum.
    Mol Biochem Parasitol. 1994 Jul;66(1):97-104 PMID: 7984191
  3. Cyclin-dependent kinases: engines, clocks, and microprocessors.
    Annu Rev Cell Dev Biol. 1997;13:261-91 PMID: 9442875
  4. Hsp90: chaperoning signal transduction.
    J Cell Physiol. 2001 Sep;188(3):281-90 PMID: 11473354
  5. Signal transduction in malaria parasites.
    Parasitol Today. 1997 Aug;13(8):307-13 PMID: 15275057
  6. A plasmodium protein kinase that is developmentally regulated, stimulated by spermine, and inhibited by quercetin.
    J Cell Biochem. 1983;21(4):305-14 PMID: 6654993
  7. Further characterization of a 58 kDa Plasmodium berghei phosphoprotein as a cochaperone.
    Mol Biochem Parasitol. 1996 Dec 2;83(1):25-33 PMID: 9010839
  8. Chaperonin-like repeats in a 34-kDa Plasmodium berghei phosphoprotein.
    Parasitol Res. 1995;81(2):167-9 PMID: 7731926
  9. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii.
    Nature. 2002 Oct 3;419(6906):512-9 PMID: 12368865
  10. Molecular characterization of the heat shock protein 90 gene of the human malaria parasite Plasmodium falciparum.
    Mol Biochem Parasitol. 1994 Sep;67(1):157-70 PMID: 7838176
  11. Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle.
    Cell. 1995 Nov 17;83(4):589-98 PMID: 7585962
  12. Molecular characterization of a Plasmodium chabaudi erythrocyte membrane-associated protein with glutamate-rich tandem repeats.
    J Eukaryot Microbiol. 1998 Sep-Oct;45(5):528-34 PMID: 9783454
  13. Accessibility and distribution of intraerythrocytic antigens of Plasmodium-infected erythrocytes following mild glutaraldehyde fixation and detergent extraction.
    Parasitol Res. 1993;79(7):579-86 PMID: 8278340
  14. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein.
    Mol Endocrinol. 1996 Apr;10(4):420-31 PMID: 8721986
  15. An overview of Plasmodium protein kinases.
    Parasitol Today. 1999 Nov;15(11):449-54 PMID: 10511687
  16. Characterization of a novel serine/threonine protein phosphatase (PfPPJ) from the malaria parasite, Plasmodium falciparum.
    Mol Biochem Parasitol. 2001 Jun;115(1):29-39 PMID: 11377737
  17. The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts.
    Genetics. 1999 Dec;153(4):1561-72 PMID: 10581266
  18. Proteolysis of a 34 kDa phosphoprotein coincident with a decrease in protein kinase activity during the erythrocytic schizont stage of the malaria parasite.
    J Eukaryot Microbiol. 1995 Nov-Dec;42(6):659-64 PMID: 8520577
  19. Identification and biochemical characterisation of a protein phosphatase 5 homologue from Plasmodium falciparum.
    Mol Biochem Parasitol. 2002 Apr 9;120(2):257-68 PMID: 11897131
  20. A novel tetratricopeptide repeat (TPR) containing PP5 serine/threonine protein phosphatase in the malaria parasite, Plasmodium falciparum.
    BMC Microbiol. 2001;1:31 PMID: 11737864
  21. Actin-binding proteins of invasive malaria parasites and the regulation of actin polymerization by a complex of 32/34-kDa proteins associated with heat shock protein 70kDa.
    Mol Biochem Parasitol. 1998 Jun 1;93(2):295-308 PMID: 9662713
  22. Cloning and characterization of a ribosomal RNA gene from Plasmodium berghei.
    Mol Biochem Parasitol. 1983 Jul;8(3):263-79 PMID: 6353227
  23. Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone.
    J Biol Chem. 2000 Jul 28;275(30):23045-52 PMID: 10811660
  24. Plasmodium berghei, P. chabaudi, and P. falciparum: similarities in phosphoproteins and protein kinase activities and their stage specific expression.
    Exp Parasitol. 1987 Dec;64(3):328-35 PMID: 3315732
  25. Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.
    Nature. 2002 Oct 3;419(6906):531-4 PMID: 12368868
  26. Cytosolic protein kinase activity associated with the maturation of the malaria parasite Plasmodium berghei.
    Mol Biochem Parasitol. 1985 Nov;17(2):179-89 PMID: 3906392
Article Info
Journal
Parasitology research
Abbr.
Parasitol Res
ISSN
0932-0113
DOI
10.1007/s00436-003-0835-4
Email
wiser@tulane.edu
Published
2003-06-00
Epub
2003-00-12
Pages
166-70
Language
English
Region
Germany
NLM ID
8703571
Subset
IM
External Links
PubMed source DOI: 10.1007/s00436-003-0835-4 View journal details
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