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PMID: 12756181 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

giant nuclei is essential in the cell cycle transition from meiosis to mitosis.

Development (Cambridge, England) ·Vol. 130 ·No. 13 ·2003-07-00 ·Pages 2997-3005

Renault AD, Zhang XH, Alphey LS, Frenz LM, Glover DM, Saunders RD, Axton JM

Abstract

At the transition from meiosis to cleavage mitoses, Drosophila requires the cell cycle regulators encoded by the genes, giant nuclei (gnu), plutonium (plu) and pan gu (png). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses. Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu.

MeSH Terms

Actins/metabolism Amino Acid Sequence Animals Base Sequence Cell Cycle Proteins/chemistry,genetics,metabolism Cell Nucleus/metabolism DNA Replication DNA-Binding Proteins/genetics,metabolism Drosophila Proteins/chemistry,genetics,metabolism Drosophila melanogaster/cytology,embryology,physiology Epistasis, Genetic Female Gene Expression Regulation, Developmental Infertility Male Meiosis/physiology Mitosis/physiology Molecular Sequence Data Oocytes/cytology,physiology Ovary/cytology,physiology Phenotype Phosphorylation Protein Processing, Post-Translational Protein Serine-Threonine Kinases/genetics,metabolism Recombinant Fusion Proteins/genetics,metabolism Recombination, Genetic Transcription Factors/genetics,metabolism Transgenes

Chemicals

Actins Cell Cycle Proteins DNA-Binding Proteins Drosophila Proteins PLU protein, Drosophila Recombinant Fusion Proteins Transcription Factors gnu protein, Drosophila png protein, Drosophila Protein Serine-Threonine Kinases

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Renault Andrew D

Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK.

Zhang Xiao-Hua

Alphey Luke S

Frenz Lisa M

Glover David M

Saunders Robert D C

Axton J Myles

Article Info

Journal

Development (Cambridge, England)

Abbr.

Development

ISSN

0950-1991

DOI

10.1242/dev.00501

Published

2003-07-00

Pages

2997-3005

Language

English

Region

England

NLM ID

8701744

Subset

Databases

GENBANK

AJ557828

External Links

PubMed source DOI: 10.1242/dev.00501 View journal details

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