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题目:: CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells.
作者:: Kim(Mi-Yeon),Gaspal(Fabrina M C),Wiggett(Helen E),McConnell(Fiona M),Gulbranson-Judge(Adam),Raykundalia(Chandra),Walker(Lucy S K),Goodall(Margaret D),Lane(Peter J L)
状态:: 发布时间2003-05-19 , 更新时间 2007-08-13
期刊:: Immunity
摘要:: In this report we identify an accessory cell that interacts with primed and memory T cells at sites where they collaborate with B cells. These cells are distinguished from conventional dendritic cells by their lack of response to Flt3 ligand and their inability to process antigen. Unlike dendritic cells, the CD4(+)CD3(-) cells have little CD80 or CD86 expression but do express high levels of the TNF ligands, OX40 ligand and CD30 ligand. We show that Th2-primed cells express the receptors for these TNF ligands and preferentially survive when cocultured with these cells. Furthermore, we show that the preferential survival of OX40(+) T cells and support of memory T cell help for B cells are linked to their association with CD4(+)CD3(-) cells in vivo.
语言:: eng
DOI:

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