Modeling network dynamics: the lac operon, a case study.

The Journal of cell biology ·Vol. 161 ·No. 3 ·2003-05-12 ·Pages 471-6

Vilar JM, Guet CC, Leibler S

Abstract

We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system.

MeSH Terms

Animals Computational Biology/methods,trends Escherichia coli/genetics,metabolism Humans Lac Operon/genetics Lactose/genetics,metabolism Models, Biological Nonlinear Dynamics

Chemicals

Lactose

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Vilar José M G

The Rockefeller University, 1230 York Avenue, Box 34, New York, NY 10021, USA. vilarj@rockefeller.edu

Guet Călin C

Leibler Stanislas

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19 references, click to expand

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Article Info

Journal

The Journal of cell biology

Abbr.

J Cell Biol

ISSN

0021-9525

DOI

10.1083/jcb.200301125

vilarj@rockefeller.edu

Published

2003-05-12

Pages

471-6

Language

English

Region

United States

NLM ID

0375356

PMCID

PMC2172934

Subset

External Links

PubMed source DOI: 10.1083/jcb.200301125 PMC Full Text View journal details

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Modeling network dynamics: the lac operon, a case study.

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