Distressing bacteria: structure of a prokaryotic detox program.

Molecular cell ·Vol. 11 ·No. 4 ·2003-04-00 ·Pages 848-50

de la Cueva-Méndez G

Abstract

MazF and MazE are components of a chromosomal toxin-antitoxin system of Escherichia coli. In this issue of Molecular Cell, Kamada et al. describe the crystal structure of a MazE/MazF heterohexamer and propose that the mechanism of toxin-antidote recognition is common to other homologous chromosomal and plasmid-borne systems.

MeSH Terms

Antitoxins/biosynthesis,genetics Bacterial Toxins/genetics,metabolism DNA-Binding Proteins/genetics,metabolism Endoribonucleases Escherichia coli/metabolism Escherichia coli Proteins Plasmids/genetics,metabolism Prokaryotic Cells/metabolism

Chemicals

Antitoxins Bacterial Toxins DNA-Binding Proteins Escherichia coli Proteins MazE protein, E coli MazF protein, E coli Endoribonucleases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

de la Cueva-Méndez Guillermo

MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom.

Article Info

Journal

Molecular cell

Abbr.

Mol Cell

ISSN

1097-2765

DOI

10.1016/s1097-2765(03)00146-1

Published

2003-04-00

Pages

848-50

Language

English

Region

United States

NLM ID

9802571

Subset

Corrections

CommentOn

PMID: 12718874

External Links

PubMed source DOI: 10.1016/s1097-2765(03)00146-1 View journal details

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