Home LiteratureArticle Details
PMID: 12702670 Published · ppublish English Historical Article Journal Article

One hundred years of mouse genetics: an intellectual history. II. The molecular revolution (1981-2002).

Genetics ·Vol. 163 ·No. 4 ·2003-04-00 ·Pages 1227-35

Paigen K

Abstract

暂无摘要

MeSH Terms
Animals Genotype History, 20th Century History, 21st Century Mice/genetics Mice, Transgenic Molecular Biology/history Phenotype
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Paigen Kenneth
The Jackson Laboratory, Bar Harbor, Maine 04609-1517, USA.
References (65)
65 references, click to expand
  1. An Oak Ridge legacy: the specific locus test and its role in mouse mutagenesis.
    Genetics. 1998 Jan;148(1):7-12 PMID: 9475716
  2. The Molecular Biology Database Collection: 2002 update.
    Nucleic Acids Res. 2002 Jan 1;30(1):1-12 PMID: 11752241
  3. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells.
    Genes Dev. 2002 Apr 15;16(8):948-58 PMID: 11959843
  4. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.
    Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5515-20 PMID: 11960009
  5. A system for stable expression of short interfering RNAs in mammalian cells.
    Science. 2002 Apr 19;296(5567):550-3 PMID: 11910072
  6. From QTL to gene: the harvest begins.
    Nat Genet. 2002 Jul;31(3):235-6 PMID: 12089518
  7. Understanding the human condition: experimental strategies in mammalian genetics.
    ILAR J. 2002;43(3):123-35 PMID: 12105380
  8. Quantitative trait loci and candidate genes regulating HDL cholesterol: a murine chromosome map.
    Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1390-401 PMID: 12231556
  9. Initial sequencing and comparative analysis of the mouse genome.
    Nature. 2002 Dec 5;420(6915):520-62 PMID: 12466850
  10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
    Nature. 2002 Dec 5;420(6915):563-73 PMID: 12466851
  11. The mosaic structure of variation in the laboratory mouse genome.
    Nature. 2002 Dec 5;420(6915):574-8 PMID: 12466852
  12. Human chromosome 21 gene expression atlas in the mouse.
    Nature. 2002 Dec 5;420(6915):582-6 PMID: 12466854
  13. A gene expression map of human chromosome 21 orthologues in the mouse.
    Nature. 2002 Dec 5;420(6915):586-90 PMID: 12466855
  14. Hereditary anemias of the mouse: a review for geneticists.
    Adv Genet. 1979;20:357-459 PMID: 390999
  15. Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.
    Proc Natl Acad Sci U S A. 1979 Nov;76(11):5818-9 PMID: 293686
  16. Genetic transformation of mouse embryos by microinjection of purified DNA.
    Proc Natl Acad Sci U S A. 1980 Dec;77(12):7380-4 PMID: 6261253
  17. Establishment in culture of pluripotential cells from mouse embryos.
    Nature. 1981 Jul 9;292(5819):154-6 PMID: 7242681
  18. Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal.
    Nature. 1981 Oct 15-21;293(5833):540-2 PMID: 7197324
  19. Introduction of a rabbit beta-globin gene into the mouse germ line.
    Nature. 1981 Nov 5;294(5836):92-4 PMID: 6945481
  20. Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring.
    Proc Natl Acad Sci U S A. 1981 Oct;78(10):6376-80 PMID: 6796959
  21. Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs.
    Cell. 1981 Nov;27(1 Pt 2):223-31 PMID: 6276022
  22. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes.
    Nature. 1982 Dec 16;300(5893):611-5 PMID: 6958982
  23. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines.
    Nature. 1984 May 17-23;309(5965):255-6 PMID: 6717601
  24. Completion of mouse embryogenesis requires both the maternal and paternal genomes.
    Cell. 1984 May;37(1):179-83 PMID: 6722870
  25. Ethylnitrosourea mutagenesis and the isolation of mutant alleles for specific genes located in the T region of mouse chromosome 17.
    Genetics. 1984 Oct;108(2):457-70 PMID: 6500258
  26. Differential activity of maternally and paternally derived chromosome regions in mice.
    Nature. 1985 Jun 6-12;315(6019):496-8 PMID: 4000278
  27. Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination.
    Nature. 1985 Sep 19-25;317(6034):230-4 PMID: 2995814
  28. Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector.
    Nature. 1986 Oct 2-8;323(6087):445-8 PMID: 3762693
  29. Transgenesis by means of blastocyst-derived embryonic stem cell lines.
    Proc Natl Acad Sci U S A. 1986 Dec;83(23):9065-9 PMID: 3024164
  30. HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells.
    Nature. 1987 Mar 19-25;326(6110):292-5 PMID: 3821905
  31. A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice.
    Nature. 1987 Mar 19-25;326(6110):295-8 PMID: 3029599
  32. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.
    Cell. 1987 Nov 6;51(3):503-12 PMID: 2822260
  33. Targetted correction of a mutant HPRT gene in mouse embryonic stem cells.
    Nature. 1987 Dec 10-16;330(6148):576-8 PMID: 3683574
  34. Biochemical defect of the hph-1 mouse mutant is a deficiency in GTP-cyclohydrolase activity.
    J Neurochem. 1988 Feb;50(2):655-7 PMID: 3335865
  35. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus.
    Nature. 1988 Sep 1;335(6185):88-9 PMID: 2457811
  36. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene.
    Cell. 1988 Oct 7;55(1):185-92 PMID: 2458842
  37. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes.
    Nature. 1988 Nov 24;336(6197):348-52 PMID: 3194019
  38. Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells.
    Cell. 1989 Jan 27;56(2):313-21 PMID: 2912572
  39. A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene.
    Am J Hum Genet. 1989 Mar;44(3):397-401 PMID: 2563634
  40. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.
    Genetics. 1989 Jan;121(1):185-99 PMID: 2563713
  41. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.
    Proc Natl Acad Sci U S A. 1989 Jul;86(14):5434-8 PMID: 2748593
  42. Hypervariability of simple sequences as a general source for polymorphic DNA markers.
    Nucleic Acids Res. 1989 Aug 25;17(16):6463-71 PMID: 2780284
  43. Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells.
    Proc Natl Acad Sci U S A. 1989 Nov;86(22):8927-31 PMID: 2573070
  44. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.
    Nature. 1990 Aug 30;346(6287):847-50 PMID: 2202907
  45. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.
    Nature. 1991 Jan 3;349(6304):84-7 PMID: 1845916
  46. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.
    Cell. 1991 Mar 8;64(5):1025-35 PMID: 1705866
  47. Parental imprinting of the mouse H19 gene.
    Nature. 1991 May 9;351(6322):153-5 PMID: 1709450
  48. Genetic analysis of autoimmune type 1 diabetes mellitus in mice.
    Nature. 1991 Jun 13;351(6327):542-7 PMID: 1675432
  49. Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.
    Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4671-4 PMID: 1711207
  50. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.
    Nature. 1992 Mar 19;356(6366):215-21 PMID: 1552940
  51. Targeted oncogene activation by site-specific recombination in transgenic mice.
    Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6232-6 PMID: 1631115
  52. Tissue- and site-specific DNA recombination in transgenic mice.
    Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6861-5 PMID: 1495975
  53. Molecular characterization of the mouse agouti locus.
    Cell. 1992 Dec 24;71(7):1195-204 PMID: 1473152
  54. ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.
    Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8977-81 PMID: 8415640
  55. MyoD or Myf-5 is required for the formation of skeletal muscle.
    Cell. 1993 Dec 31;75(7):1351-9 PMID: 8269513
  56. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.
    Science. 1994 Apr 29;264(5159):719-25 PMID: 8171325
  57. Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.
    Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9302-6 PMID: 7937760
  58. Positional cloning of the mouse obese gene and its human homologue.
    Nature. 1994 Dec 1;372(6505):425-32 PMID: 7984236
  59. Insertional mutagenesis in transgenic mice generated by the pronuclear microinjection procedure.
    Int J Dev Biol. 1998;42(7):1009-17 PMID: 9853832
  60. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci.
    Genomics. 2001 Jan 1;71(1):70-7 PMID: 11161799
  61. The origins, patterns and implications of human spontaneous mutation.
    Nat Rev Genet. 2000 Oct;1(1):40-7 PMID: 11262873
  62. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.
    Nature. 2001 May 24;411(6836):494-8 PMID: 11373684
  63. Site-specific transgene insertion: an approach.
    Reprod Fertil Dev. 1994;6(5):585-8 PMID: 7569037
  64. Control of memory formation through regulated expression of a CaMKII transgene.
    Science. 1996 Dec 6;274(5293):1678-83 PMID: 8939850
  65. Positional cloning of the mouse circadian clock gene.
    Cell. 1997 May 16;89(4):641-53 PMID: 9160755
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/163.4.1227
Published
2003-04-00
Pages
1227-35
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1462511
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/163.4.1227 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2