Home LiteratureArticle Details
PMID: 12700889 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Resistin: molecular history and prognosis.

Journal of molecular medicine (Berlin, Germany) ·Vol. 81 ·No. 4 ·2003-04-00 ·Pages 218-26

Banerjee RR, Lazar MA

Abstract

Obesity and diabetes have reached epidemic proportions worldwide. The antidiabetic thiazolidinedione (TZD) drugs are insulin-sensitizing agents now widely used in the treatment of type 2 diabetes. TZDs are ligands for the nuclear hormone receptor peroxisome proliferator activated receptor gamma, which is a master regulator of adipogenesis and adipocyte metabolism. The molecular mechanisms by which TZDs improve insulin sensitivity have not been fully identified. Here we consider a novel secreted factor first identified as a TZD-suppressible gene in mouse adipocytes, called resistin, and discuss what is currently known about resistin regulation and function in mouse and human.

MeSH Terms
Amino Acid Sequence Animals Gene Expression Regulation Glucocorticoids/metabolism Glucose/metabolism Hormones, Ectopic/genetics,physiology Hypoglycemic Agents/therapeutic use Insulin/metabolism Intercellular Signaling Peptides and Proteins Ligands Mice Molecular Sequence Data NIH 3T3 Cells Nerve Growth Factor Obesity/genetics Protein Structure, Tertiary Proteins Resistin Sequence Homology, Amino Acid Thiazolidinediones/therapeutic use
Chemicals
Glucocorticoids Hormones, Ectopic Hypoglycemic Agents Insulin Intercellular Signaling Peptides and Proteins Ligands Proteins RETNLB protein, human Resistin Retn protein, mouse Retnla protein, mouse Thiazolidinediones Nerve Growth Factor 2,4-thiazolidinedione Glucose
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Banerjee Ronadip R
Division of Endocrinology, Diabetes, and Metabolism, Penn Diabetes Center, University of Pennsylvania School of Medicine, 415 Curie Blvd., Philadelphia, PA 19104-6149, USA.
Lazar Mitchell A
References (75)
75 references, click to expand
  1. Thiazolidinediones: a new class of antidiabetic drugs.
    Diabet Med. 1999 Mar;16(3):179-92 PMID: 10227562
  2. You are what you secrete.
    Nat Med. 2001 Aug;7(8):887-8 PMID: 11479613
  3. Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats.
    Endocrinology. 2002 Jun;143(6):2445-8 PMID: 12021211
  4. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production.
    J Clin Invest. 2003 Jan;111(2):225-30 PMID: 12531878
  5. Systematic search for single nucleotide polymorphisms in the resistin gene: the absence of evidence for the association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes.
    Diabetes. 2002 Mar;51(3):863-6 PMID: 11872693
  6. Resistin, central obesity, and type 2 diabetes.
    Lancet. 2002 Jan 5;359(9300):46-7 PMID: 11809189
  7. A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes.
    Mol Cell Proteomics. 2002 Mar;1(3):213-22 PMID: 12096121
  8. Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.
    Diabetes. 2002 Jun;51(6):1737-44 PMID: 12031960
  9. Obesity and insulin resistance.
    J Clin Invest. 2000 Aug;106(4):473-81 PMID: 10953022
  10. Obesity and the regulation of energy balance.
    Cell. 2001 Feb 23;104(4):531-43 PMID: 11239410
  11. Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice.
    Biochem Biophys Res Commun. 2001 Aug 31;286(4):735-41 PMID: 11520059
  12. Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans.
    Diabetes. 2001 Oct;50(10):2199-202 PMID: 11574398
  13. Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension.
    Nature. 1999 Dec 23-30;402(6764):880-3 PMID: 10622252
  14. Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA.
    Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1266-71 PMID: 12388167
  15. Decreased resistin expression in mice with different sensitivities to a high-fat diet.
    Biochem Biophys Res Commun. 2001 Nov 30;289(2):564-7 PMID: 11716511
  16. Adipose tissue as an endocrine organ.
    Trends Endocrinol Metab. 2000 Oct;11(8):327-32 PMID: 10996528
  17. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes.
    Cell. 2001 Feb 23;104(4):517-29 PMID: 11239409
  18. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
    Nat Genet. 2000 Oct;26(2):163-75 PMID: 11017071
  19. Increased resistin expression in the adipose tissue of male prolactin transgenic mice and in male mice with elevated androgen levels.
    FEBS Lett. 2001 Oct 26;507(2):147-50 PMID: 11684088
  20. Roles of PPARs in health and disease.
    Nature. 2000 May 25;405(6785):421-4 PMID: 10839530
  21. A central role for JNK in obesity and insulin resistance.
    Nature. 2002 Nov 21;420(6913):333-6 PMID: 12447443
  22. Expression of resistin in the adipose tissue is modulated by various factors including peroxisome proliferator-activated receptor alpha.
    Diabetes Obes Metab. 2002 Sep;4(5):342-5 PMID: 12190998
  23. Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus.
    Ann N Y Acad Sci. 2002 Jun;967:363-78 PMID: 12079864
  24. Inhibition by insulin of resistin gene expression in 3T3-L1 adipocytes.
    FEBS Lett. 2001 Oct 19;507(1):105-8 PMID: 11682067
  25. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.
    J Biol Chem. 2002 Dec 27;277(52):50230-6 PMID: 12006582
  26. Suppressed gene expression of adipocyte resistin in an insulin-resistant rat model probably by elevated free fatty acids.
    Biochem Biophys Res Commun. 2001 Dec 21;289(5):1328-33 PMID: 11741341
  27. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?
    Diabetes. 2002 Oct;51(10):2951-8 PMID: 12351432
  28. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators.
    Biochem Biophys Res Commun. 2003 Jan 10;300(2):472-6 PMID: 12504108
  29. Increased resistin gene and protein expression in human abdominal adipose tissue.
    J Clin Endocrinol Metab. 2002 May;87(5):2407 PMID: 11994397
  30. Differential dimerization and association among resistin family proteins with implications for functional specificity.
    J Endocrinol. 2002 Nov;175(2):499-504 PMID: 12429047
  31. Role of leptin in the neuroendocrine response to fasting.
    Nature. 1996 Jul 18;382(6588):250-2 PMID: 8717038
  32. Leptin.
    Annu Rev Physiol. 2000;62:413-37 PMID: 10845097
  33. Lipopolysaccharide increases resistin gene expression in vivo and in vitro.
    FEBS Lett. 2002 Oct 23;530(1-3):158-62 PMID: 12387885
  34. Association of resistin gene 3'-untranslated region +62G-->A polymorphism with type 2 diabetes and hypertension in a Chinese population.
    J Clin Endocrinol Metab. 2003 Mar;88(3):1258-63 PMID: 12629116
  35. Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle.
    Biochem Biophys Res Commun. 2001 Jul 13;285(2):561-4 PMID: 11444881
  36. Differential gene regulation by PPARgamma agonist and constitutively active PPARgamma2.
    Mol Endocrinol. 2002 May;16(5):1040-8 PMID: 11981038
  37. Free fatty acids and pathogenesis of type 2 diabetes mellitus.
    Trends Endocrinol Metab. 2000 Nov;11(9):351-6 PMID: 11042464
  38. Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue.
    Mol Endocrinol. 2002 Aug;16(8):1920-30 PMID: 12145345
  39. Human resistin gene, obesity, and type 2 diabetes: mutation analysis and population study.
    Diabetes. 2002 Mar;51(3):860-2 PMID: 11872692
  40. Resistin and obesity-associated insulin resistance.
    Trends Endocrinol Metab. 2002 Jan-Feb;13(1):18-23 PMID: 11750858
  41. Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones.
    J Clin Invest. 2000 Nov;106(10 ):1221-8 PMID: 11086023
  42. Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytes.
    FEBS Lett. 2001 Jun 29;500(1-2):60-3 PMID: 11434927
  43. The hormone resistin links obesity to diabetes.
    Nature. 2001 Jan 18;409(6818):307-12 PMID: 11201732
  44. Peroxisome proliferator-activated receptor gamma and metabolic disease.
    Annu Rev Biochem. 2001;70:341-67 PMID: 11395411
  45. Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules.
    Biochem Biophys Res Commun. 2002 Nov 29;299(2):291-8 PMID: 12437985
  46. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
    Nat Med. 2001 Aug;7(8):941-6 PMID: 11479627
  47. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists.
    J Clin Invest. 2000 Aug;106(4):467-72 PMID: 10953021
  48. Mechanisms by which Thiazolidinediones Enhance Insulin Action.
    Trends Endocrinol Metab. 1999 Dec;10(1):9-13 PMID: 10322388
  49. 5' flanking variants of resistin are associated with obesity.
    Diabetes. 2002 May;51(5):1629-34 PMID: 11978666
  50. Resistin expression and regulation in mouse pituitary.
    FEBS Lett. 2002 Aug 28;526(1-3):26-30 PMID: 12208498
  51. Insulin resistance as the core defect in type 2 diabetes mellitus.
    Am J Cardiol. 2002 Sep 5;90(5A):3G-10G PMID: 12231073
  52. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action.
    Nat Med. 2001 Aug;7(8):947-53 PMID: 11479628
  53. Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians.
    J Clin Endocrinol Metab. 2002 Jun;87(6):2520-4 PMID: 12050208
  54. A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation.
    J Biol Chem. 2001 Apr 6;276(14):11252-6 PMID: 11278254
  55. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists.
    J Biol Chem. 2001 Jul 13;276(28):25651-3 PMID: 11373275
  56. Dimerization of resistin and resistin-like molecules is determined by a single cysteine.
    J Biol Chem. 2001 Jul 13;276(28):25970-3 PMID: 11358969
  57. Genetic variants at the resistin locus and risk of type 2 diabetes in Caucasians.
    J Clin Endocrinol Metab. 2002 Sep;87(9):4407-10 PMID: 12213908
  58. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
    Diabetes. 2001 Sep;50(9):2094-9 PMID: 11522676
  59. Transcriptional control of adipogenesis.
    Annu Rev Nutr. 2000;20:535-59 PMID: 10940345
  60. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family.
    EMBO J. 2000 Aug 1;19(15):4046-55 PMID: 10921885
  61. An ATG repeat in the 3'-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance.
    J Clin Endocrinol Metab. 2002 Sep;87(9):4403-6 PMID: 12213907
  62. Mechanisms regulating adipocyte expression of resistin.
    J Biol Chem. 2002 May 31;277(22):19754-61 PMID: 11901161
  63. Molecular regulation of adipogenesis.
    Annu Rev Cell Dev Biol. 2000;16:145-71 PMID: 11031233
  64. Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes.
    Biochem Biophys Res Commun. 2001 Nov 9;288(4):1027-31 PMID: 11689013
  65. Single nucleotide polymorphisms of the resistin (RSTN) gene.
    J Hum Genet. 2001;46(9):553-5 PMID: 11558907
  66. The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism.
    Diabetes. 2002 Aug;51(8):2341-7 PMID: 12145143
  67. Resistin gene expression in human adipocytes is not related to insulin resistance.
    Obes Res. 2002 Jan;10(1):1-5 PMID: 11786595
  68. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.
    Eur J Clin Invest. 2002 Jun;32 Suppl 3:14-23 PMID: 12028371
  69. Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity.
    Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1334-41 PMID: 12006364
  70. Becoming fat.
    Genes Dev. 2002 Jan 1;16(1):1-5 PMID: 11782439
  71. A transgenic model of visceral obesity and the metabolic syndrome.
    Science. 2001 Dec 7;294(5549):2166-70 PMID: 11739957
  72. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism.
    Trends Endocrinol Metab. 2002 Mar;13(2):84-9 PMID: 11854024
  73. A family of tissue-specific resistin-like molecules.
    Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):502-6 PMID: 11209052
  74. Cellular mechanisms of insulin resistance.
    J Clin Invest. 2000 Jul;106(2):171-6 PMID: 10903330
  75. Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats.
    Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E626-33 PMID: 11832366
Article Info
Journal
Journal of molecular medicine (Berlin, Germany)
Abbr.
J Mol Med (Berl)
ISSN
0946-2716
DOI
10.1007/s00109-003-0428-9
Published
2003-04-00
Epub
2003-00-28
Pages
218-26
Language
English
Region
Germany
NLM ID
9504370
Subset
IM
Grants
NIDDK NIH HHS · DK19525 · United States
NIDDK NIH HHS · DK49210 · United States
NIDDK NIH HHS · DK49780 · United States
External Links
PubMed source DOI: 10.1007/s00109-003-0428-9 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2