Home LiteratureArticle Details
PMID: 12690530 Published · ppublish English Journal Article

Proliferation rate of intracranial meningiomas as defined by the monoclonal antibody MIB-1: correlation with peritumoural oedema and other clinicoradiological and histological characteristics.

Neurosurgical review ·Vol. 26 ·No. 3 ·2003-07-00 ·Pages 221-8

Aguiar PH, Tsanaclis AM, Tella OI, Plese JP

Abstract

Paraffin-embedded surgical specimens from 55 meningiomas were immunostained after microwave processing using the streptavidin/peroxidase method and the monoclonal antibody (moAb) MIB-1 to the Ki-67 antigen. The authors assessed proliferative labelling index (LI) from a series of surgically removed meningiomas using immunohistochemical methods and MIB-1, and they correlated this index with clinical, radiological, and histological factors. No relationship was found between LI, sex, age, resection and histological grades, or volume. Symptoms, location, and peritumoural oedema did have a significant relationship to the MIB-1 LI. The symptomatic patients, i.e. those with tumours at the base of the skull and with GR3 peritumoural oedema (grade 3), had a greater chance of higher MIB-1 LI. It was proven that the increase of one unit in peritumoural oedema classification gave an increased risk of 3.312 and an LI greater than 3%. The authors also discuss the different methods of evaluating LIs in meningiomas, based on the available literature.

MeSH Terms
Adolescent Adult Aged Aged, 80 and over Antibodies, Antinuclear/immunology Antibodies, Monoclonal/immunology Brain Edema/diagnosis,etiology,immunology Brain Neoplasms/complications,diagnosis,immunology Cell Division/immunology Child Female Humans Magnetic Resonance Imaging Male Meningioma/complications,diagnosis,immunology Middle Aged Tomography, X-Ray Computed
Chemicals
Antibodies, Antinuclear Antibodies, Monoclonal MIB-1 antibody
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Aguiar Paulo Henrique
Department of Neurosurgery, São Paulo Medical School, São Paulo, Brazil. phpaneurocir@aol.com
Tsanaclis Ana Maria
Tella Oswaldo Inácio
Plese José Pindaro
References (72)
72 references, click to expand
  1. Observation on peritumoural oedema in meningioma. Part I: Distribution, spread and resolution of vasogenic oedema seen on computed tomography.
    Neuroradiology. 1983;25(2):71-80 PMID: 6877589
  2. Clear cell meningioma. A clinicopathologic study of a potentially aggressive variant of meningioma.
    Am J Surg Pathol. 1995 May;19(5):493-505 PMID: 7726360
  3. Immunohistochemical detection of female sex hormone receptors in meningiomas: correlation with clinical and histological features.
    Neurosurgery. 1993 Aug;33(2):212-7; discussion 217-8 PMID: 8367042
  4. The labelling of proliferating cells by Ki67 and MIB-1 antibodies depends on the binding of a nuclear protein to the DNA.
    Exp Cell Res. 1994 Feb;210(2):145-53 PMID: 8299712
  5. The implications of the heterogeneous distribution of Ki-67 labelled cells in meningiomas.
    Br J Neurosurg. 1989;3(1):101-7 PMID: 2789703
  6. The monoclonal antibody Ki-67 as a marker for proliferating cells in stereotactic biopsies of brain tumours.
    Acta Neurochir (Wien). 1987;89(3-4):117-21 PMID: 3324650
  7. Ki-67 detects a nuclear matrix-associated proliferation-related antigen. I. Intracellular localization during interphase.
    J Cell Sci. 1989 Jan;92 ( Pt 1):123-30 PMID: 2674163
  8. The significance of nucleolar organizer region (AgNOR) score in predicting meningioma recurrence.
    Cancer. 1994 Apr 15;73(8):2200-5 PMID: 8156526
  9. The use of the monoclonal antibody Ki-67 in the identification of proliferating cells: application to surgical neuropathology.
    Am J Surg Pathol. 1986 Sep;10(9):611-7 PMID: 2428262
  10. Meningiomas: clinical implications of a high proliferative potential determined by bromodeoxyuridine labeling.
    Neurosurgery. 1992 Apr;30(4):494-7; discussion 497-8 PMID: 1584346
  11. Cell-kinetic characteristics of human brain tumors.
    Oncology. 1990;47(4):344-51 PMID: 2367061
  12. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation.
    Int J Cancer. 1983 Jan 15;31(1):13-20 PMID: 6339421
  13. Computerized tomography scanning appearances of intracranial meningiomas. An attempt to predict the histological features.
    J Neurosurg. 1979 Mar;50(3):320-7 PMID: 570597
  14. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections.
    J Pathol. 1992 Dec;168(4):357-63 PMID: 1484317
  15. The proliferation rate of intracranial tumors as defined by the monoclonal antibody KI 67. Application of the method to paraffin embedded specimens.
    Neurosurg Rev. 1988;11(3-4):267-72 PMID: 2855108
  16. Proliferation potential and histological features in neurofibromatosis 2-associated and sporadic meningiomas.
    J Neurosurg. 1997 Oct;87(4):610-4 PMID: 9322850
  17. Identification of proliferating cells in human gliomas using the monoclonal antibody Ki-67.
    Neurosurgery. 1988 Feb;22(2):364-8 PMID: 2832782
  18. Proliferation activity in pituitary adenomas: measurement by monoclonal antibody Ki-67.
    Neurosurgery. 1989 Dec;25(6):927-30 PMID: 2601824
  19. MIB-1 immunostaining and DNA flow cytometry in meningiomas.
    Noshuyo Byori. 1996 Apr;13(1):17-20 PMID: 8916122
  20. Biological features of meningiomas that determine the production of cerebral edema.
    Neurosurgery. 1981 Apr;8(4):428-33 PMID: 7242894
  21. Proliferative potential of meningiomas evaluated by proliferating cell nuclear antigen expression.
    J Neurooncol. 1995;24(3):209-17 PMID: 7595751
  22. Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors.
    Acta Neuropathol. 1989;78(2):166-75 PMID: 2750486
  23. Peritumoral edema in meningiomas. A radiological and histological study.
    Neuroradiology. 1986;28(4):304-12 PMID: 3762907
  24. A commentary on the biology and growth kinetics of low-grade and high-grade gliomas.
    J Neurosurg. 1984 Nov;61(5):895-900 PMID: 6491735
  25. The recurrence of intracranial meningiomas after surgical treatment.
    J Neurol Neurosurg Psychiatry. 1957 Feb;20(1):22-39 PMID: 13406590
  26. Volume determinations using computed tomography.
    AJR Am J Roentgenol. 1982 Feb;138(2):329-33 PMID: 6976739
  27. Cell kinetic analyses of human malignant brain tumors (gliomas).
    Cancer. 1979 Sep;44(3):956-62 PMID: 225007
  28. Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67.
    Am J Pathol. 1991 Apr;138(4):867-73 PMID: 2012175
  29. Significance of proliferating cell nuclear antigen in predicting recurrence of intracranial meningioma.
    J Neurosurg. 1996 Jan;84(1):85-90 PMID: 8613841
  30. The cell cycle.
    N Engl J Med. 1981 Feb 19;304(8):453-9 PMID: 6161307
  31. Proliferative potential of meningiomas determined with the monoclonal antibody Ki-67.
    Acta Neuropathol. 1987;73(4):361-4 PMID: 3618128
  32. Immunohistochemical detection of progesterone receptors and the correlation with Ki-67 labeling indices in paraffin-embedded sections of meningiomas.
    Neurosurgery. 1995 Sep;37(3):478-82; discussion 483 PMID: 7501113
  33. Detection of the Ki-67 antigen in fixed and wax-embedded sections with the monoclonal antibody MIB1.
    Histopathology. 1993 Apr;22(4):355-60 PMID: 8514278
  34. Meningioma: proliferating potential and clinicoradiological features.
    Neurosurgery. 1995 Dec;37(6):1049-55 PMID: 8584144
  35. Argyrophilic nucleolar organizer region proteins (Ag-NORs) in human brain tumors: relations with grade of malignancy and proliferation indices.
    Acta Neuropathol. 1990;80(2):156-62 PMID: 2389680
  36. Malignant meningioma: a clinicopathologic study of 23 patients including MIB1 and p53 immunohistochemistry.
    Am J Clin Pathol. 1996 Jun;105(6):719-26 PMID: 8659446
  37. Proliferating cell nuclear antigen immunoreactivity in human central nervous system neoplasms.
    Acta Neuropathol. 1993;85(3):316-22 PMID: 7681617
  38. MIB1 staining index and scoring of histologic features in meningioma. Indicators for the prediction of biologic potential and postoperative management.
    Cancer. 1994 Dec 15;74(12):3176-89 PMID: 7982181
  39. Tumor cell growth fractions in human malignant melanomas and the correlation to histopathologic tumor grading.
    Am J Pathol. 1989 May;134(5):1063-8 PMID: 2719076
  40. MIB-1 staining index and peritumoral brain edema of meningiomas.
    Cancer. 1996 Jul 1;78(1):133-43 PMID: 8646709
  41. Growth rate of intracranial meningioma: tumor doubling time and proliferating cell nuclear antigen staining index.
    Neurol Med Chir (Tokyo). 1995 May;35(5):289-93 PMID: 7623949
  42. Determination of the proliferative potential of human brain tumors using the monoclonal antibody Ki-67.
    J Cancer Res Clin Oncol. 1989;115(2):179-88 PMID: 2715168
  43. Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
    J Neurosurg. 1968 Jun;28(6):530-8 PMID: 4233585
  44. The relationship between Ki-67 labeling and mitotic index in gliomas and meningiomas: demonstration of the variability of the intermitotic cycle time.
    Acta Neuropathol. 1991;82(5):389-94 PMID: 1767633
  45. Peritumoral brain edema in meningiomas--influence of vascular supply on its development.
    Neurosurgery. 1992 Aug;31(2):179-85 PMID: 1513424
  46. Cerebral edema associated with meningiomas.
    Surg Neurol. 1987 Jan;27(1):64-8 PMID: 3787443
  47. Growth fraction in human brain tumors defined by the monoclonal antibody Ki-67.
    Acta Neuropathol. 1987;74(2):179-82 PMID: 3673508
  48. Atypical and anaplastic meningiomas: radiology, surgery, radiotherapy, and outcome.
    Surg Neurol. 1986 Mar;25(3):233-42 PMID: 3945904
  49. Peritumoral blood flow in intracranial meningiomas.
    Neurosurgery. 1991 Mar;28(3):400-4 PMID: 2011222
  50. Quantitative imaging of estrogen and progesterone receptors, estrogen-regulated protein, and growth fraction: immunocytochemical assays in 52 meningiomas. Correlation with clinical and morphological data.
    J Neurosurg. 1994 Nov;81(5):765-73 PMID: 7523635
  51. Comparison of MIB-1 (Ki-67) antigen and bromodeoxyuridine proliferation indices in meningiomas.
    Hum Pathol. 1996 Apr;27(4):350-4 PMID: 8617477
  52. The correlation of growth fractions with histologic grading and lymph node status in human mammary carcinoma.
    Cancer. 1987 Jan 1;59(1):83-8 PMID: 2431758
  53. Relationship between Ki-67 positive cells, growth rate and histological type of human intracranial tumors.
    Anticancer Res. 1988 Jul-Aug;8(4):537-44 PMID: 3052245
  54. Influence of preoperative dexamethasone therapy on proliferating cell nuclear antigen (PCNA) expression in comparison to other parameters in meningiomas.
    Histol Histopathol. 1992 Oct;7(4):653-61 PMID: 1360848
  55. In situ analysis of cell kinetics in human brain tumors. A comparative immunocytochemical study of S phase cells by a new in vitro bromodeoxyuridine-labeling technique, and of proliferating pool cells by monoclonal antibody Ki-67.
    Acta Neuropathol. 1989;77(3):276-82 PMID: 2922990
  56. Peritumoral brain edema and cortical damage by meningioma.
    Acta Neurochir Suppl (Wien). 1994;60:369-72 PMID: 7976592
  57. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections.
    J Histochem Cytochem. 1991 Jun;39(6):741-8 PMID: 1709656
  58. The growth rate of intracranial meningiomas and its relation to histology. An analysis of 43 patients.
    Surg Neurol. 1985 Aug;24(2):165-72 PMID: 4012573
  59. Proliferative activity of acoustic neurilemomas without neurofibromatosis determined by monoclonal antibody MIB 1.
    Acta Neurochir (Wien). 1995;134(1-2):35-9 PMID: 7668123
  60. Nucleolar organizer region score and Ki-67 labelling index in high-grade gliomas and metastatic brain tumours.
    Acta Neurochir (Wien). 1991;109(1-2):37-41 PMID: 1648862
  61. Ki-67 immunoreactivity in human central nervous system tumors: a study with MIB 1 monoclonal antibody on archival material.
    Acta Neuropathol. 1994;87(1):47-54 PMID: 7511316
  62. The cycling pool of cells within human brain tumors: in situ cytokinetics using the monoclonal antibody Ki-67.
    Can J Neurol Sci. 1991 Feb;18(1):12-7 PMID: 1645210
  63. Ki-67 detects a nuclear matrix-associated proliferation-related antigen. II. Localization in mitotic cells and association with chromosomes.
    J Cell Sci. 1989 Apr;92 ( Pt 4):531-40 PMID: 2689459
  64. Growth fractions in breast cancers determined in situ with monoclonal antibody Ki-67.
    J Clin Pathol. 1986 Sep;39(9):977-80 PMID: 3020096
  65. [Analysis of the proliferative potential of meningiomas with MIB-1 monoclonal antibodies].
    No To Shinkei. 1996 Jan;48(1):39-43 PMID: 8679317
  66. Factors affecting operative and excess long-term mortality in 935 patients with intracranial meningioma.
    Neurosurgery. 1992 Jul;31(1):2-12 PMID: 1641106
  67. DNA in meningioma tissues and explant cell cultures. A flow cytometric study with clinicopathological correlates.
    J Neurosurg. 1987 Apr;66(4):588-94 PMID: 3559726
  68. Proliferative potential of human meningiomas of the brain. A cell kinetics study with bromodeoxyuridine.
    Cancer. 1986 Oct 1;58(7):1466-72 PMID: 2427189
  69. Proliferative potential of brain tumors. Analyses with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine labeling, and nuclear organizer region counts.
    Cancer. 1993 Jan 1;71(1):199-206 PMID: 8416716
  70. The comparison between the growth fraction of bilateral vestibular schwannomas in neurofibromatosis 2 (NF2) and unilateral vestibular schwannomas using the monoclonal antibody MIB 1.
    Acta Neurochir (Wien). 1995;134(1-2):40-5 PMID: 7668124
  71. Growth fractions in malignant non-Hodgkin's lymphomas (NHL) as determined in situ with the monoclonal antibody Ki-67.
    Hematol Oncol. 1984 Oct-Dec;2(4):365-71 PMID: 6396192
  72. Correlation between sex hormone receptors and peritumoral edema in intracranial meningiomas.
    J Neurosurg Sci. 1994 Mar;38(1):29-33 PMID: 7965139
Article Info
Journal
Neurosurgical review
Abbr.
Neurosurg Rev
ISSN
0344-5607
DOI
10.1007/s10143-003-0261-1
Email
phpaneurocir@aol.com
Published
2003-07-00
Epub
2003-00-08
Pages
221-8
Language
English
Region
Germany
NLM ID
7908181
Subset
IM
External Links
PubMed source DOI: 10.1007/s10143-003-0261-1 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2