A stress sensor for the bacterial periplasm.

Cell ·Vol. 113 ·No. 1 ·2003-04-04 ·Pages 1-2

Young JC, Hartl FU

Abstract

DegS, the periplasmic stress sensor, becomes activated when its PDZ domain recognizes the improperly exposed C-terminal sequences of outer membrane porins. This interaction relieves the inhibition of the neighboring protease domain of DegS, triggering a proteolysis cascade that leads to the sigma(E)-driven expression of periplasmic chaperones.

MeSH Terms

Bacteria/metabolism Bacterial Proteins/metabolism Periplasm/metabolism Protein Folding Protein Structure, Tertiary/physiology Signal Transduction/physiology Transcription Factors/physiology

Chemicals

Bacterial Proteins DegS protein, Bacteria Transcription Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Young Jason C

Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

Hartl F Ulrich

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/s0092-8674(03)00192-2

Published

2003-04-04

Pages

1-2

Language

English

Region

United States

NLM ID

0413066

Subset

Corrections

CommentIn

PMID: 12679035

External Links

PubMed source DOI: 10.1016/s0092-8674(03)00192-2 View journal details

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A stress sensor for the bacterial periplasm.

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