Home LiteratureArticle Details
PMID: 12654694 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

mecA-blaZ corepressors in clinical Staphylococcus aureus isolates.

Antimicrobial agents and chemotherapy ·Vol. 47 ·No. 4 ·2003-04-00 ·Pages 1460-3

Rosato AE, Kreiswirth BN, Craig WA, Eisner W, Climo MW, Archer GL

Abstract

The presence and nucleotide sequences of the two mecA repressors, mecI and blaI, were assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were grouped into unique clonal types based on their spa nucleotide repeat patterns. Forty-three of the 45 (96%) isolates with mutant mecI or with a deletion of mecI contained blaI, while blaI was present in only 21 of 28 (78%) isolates with wild-type mecI (P < 0.05). Among 22 additional isolates that did not contain blaI, all had wild-type mecI sequences. We conclude that oxacillin-resistant S. aureus must have at least one of the two functional mecA regulators.

MeSH Terms
Bacterial Proteins Carrier Proteins/genetics Hexosyltransferases Humans Muramoylpentapeptide Carboxypeptidase/genetics Oxacillin/pharmacology Penicillin-Binding Proteins Peptidyl Transferases Repressor Proteins/analysis Staphylococcus aureus/drug effects,genetics beta-Lactamases/genetics
Chemicals
Bacterial Proteins Carrier Proteins MecI protein, Staphylococcus Penicillin-Binding Proteins Repressor Proteins Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase beta-Lactamases Oxacillin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Rosato Adriana E
Department of Medicine, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia 23298, USA.
Kreiswirth Barry N
Craig William A
Eisner William
Climo Michael W
Archer Gordon L
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.47.4.1460-1463.2003
Published
2003-04-00
Pages
1460-3
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC152515
Subset
IM
Grants
NIAID NIH HHS · R37 AI035705 · United States
NIAID NIH HHS · R37 AI 35705 · United States
External Links
PubMed source DOI: 10.1128/AAC.47.4.1460-1463.2003 PMC Full Text View journal details
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