Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain.

Microbes and infection ·Vol. 5 ·No. 2 ·2003-02-00 ·Pages 135-42

Elkins KL, Cowley SC, Bosio CM

Abstract

The immune response to intracellular bacterium, Francisella tularensis, which causes tularemia and is proposed to be a potential bioterrorism pathogen, has been studied in mice using the attenuated live vaccine strain (LVS). Here we review this infection model, which provides a convenient means of studying protective immune mechanisms not only for Francisella, but also for the large and important class of intracellular pathogens.

MeSH Terms

Animals Antibodies, Bacterial/blood Bacterial Vaccines/administration & dosage,immunology Disease Models, Animal Francisella tularensis/immunology Immunity, Cellular Immunity, Innate Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Knockout Tularemia/immunology,prevention & control Vaccination Vaccines, Attenuated/administration & dosage,immunology

Chemicals

Antibodies, Bacterial Bacterial Vaccines Vaccines, Attenuated

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Elkins Karen L

Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA. elkins@cber.fda.gov

Cowley Siobhán C

Bosio Catharine M

Article Info

Journal

Microbes and infection

Abbr.

Microbes Infect

ISSN

1286-4579

DOI

10.1016/s1286-4579(02)00084-9

elkins@cber.fda.gov

Published

2003-02-00

Pages

135-42

Language

English

Region

France

NLM ID

100883508

Subset

External Links

PubMed source DOI: 10.1016/s1286-4579(02)00084-9 View journal details

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Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain.

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