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PMID: 12650604 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

MKK4 and metastasis suppression: a marriage of signal transduction and metastasis research.

Clinical & experimental metastasis ·Vol. 20 ·No. 1 ·2003-00-00 ·Pages 25-30

Robinson VL, Hickson JA, Vander Griend DJ, Dubauskas Z, Rinker-Schaeffer CW

Abstract

MAP kinase kinase 4 (MKK4) is a member of the stress-activated protein kinase (SAPK) signaling cascade and is involved in the regulation of many cellular processes. We have recently demonstrated a functional role for MKK4 in the suppression of metastases. In this review, we discuss the established cellular and biochemical functions of MKK4, as well as a new function for MKK4 as a metastasis suppressor gene. Because of the importance of signaling studies to this translational work, a detailed example of the strategy and tools that can be employed to define the biochemical mechanism of MKK4-mediated metastasis suppression is presented. Finally, the potential therapeutic utility of these findings is discussed.

MeSH Terms
Animals Cells, Cultured Genes, Tumor Suppressor Humans MAP Kinase Kinase 4 Mice Mitogen-Activated Protein Kinase Kinases/genetics,physiology Models, Biological Neoplasm Metastasis Signal Transduction
Chemicals
MAP Kinase Kinase 4 MAP2K4 protein, human Map2k4 protein, mouse Mitogen-Activated Protein Kinase Kinases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Robinson Victoria L
Section of Urology, Department of Surgery, The University of Chicago (The Committee on Cancer Biology), University of Chicago, Chicago, Illinois 60637, USA.
Hickson Jonathan A
Vander Griend Donald J
Dubauskas Zita
Rinker-Schaeffer Carrie W
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Article Info
Journal
Clinical & experimental metastasis
Abbr.
Clin Exp Metastasis
ISSN
0262-0898
DOI
10.1023/a:1022586318678
Published
2003-00-00
Pages
25-30
Language
English
Region
Netherlands
NLM ID
8409970
Subset
IM
Grants
NCI NIH HHS · 1 R01 CA 89569 · United States
NCI NIH HHS · 5 T32 CA 09594 · United States
External Links
PubMed source DOI: 10.1023/a:1022586318678 View journal details
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