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PMID: 12644510 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Biofilm formation by hyperpiliated mutants of Pseudomonas aeruginosa.

Journal of bacteriology ·Vol. 185 ·No. 7 ·2003-04-00 ·Pages 2374-8

Chiang P, Burrows LL

Abstract

Under static growth conditions, hyperpiliated, nontwitching pilT and pilU mutants of Pseudomonas aeruginosa formed dense biofilms, showing that adhesion, not twitching motility, is necessary for biofilm initiation. Under flow conditions, the pilT mutant formed mushroom-like structures larger than those of the wild type but the pilU mutant was defective in biofilm formation. Therefore, twitching motility affects the development of biofilm structure, possibly through modulation of detachment.

MeSH Terms
Adenosine Triphosphatases/genetics Bacterial Adhesion/physiology Bacterial Proteins Biofilms/growth & development Fimbriae Proteins/genetics Fimbriae, Bacterial/physiology Glass Molecular Motor Proteins/genetics Movement Mutation Pseudomonas aeruginosa/physiology
Chemicals
Bacterial Proteins Molecular Motor Proteins PilU protein, Pseudomonas aeruginosa Fimbriae Proteins Adenosine Triphosphatases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chiang Poney
Centre for Infection and Biomaterials Research, Hospital for Sick Children, and Department of Surgery, University of Toronto, Toronto, Canada.
Burrows Lori L
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.185.7.2374-2378.2003
Published
2003-04-00
Pages
2374-8
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC151504
Subset
IM
External Links
PubMed source DOI: 10.1128/JB.185.7.2374-2378.2003 PMC Full Text View journal details
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