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PMID: 12634795 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

From words to literature in structural proteomics.

Nature ·Vol. 422 ·No. 6928 ·2003-03-13 ·Pages 216-25

Sali A, Glaeser R, Earnest T, Baumeister W

Abstract

Technical advances on several frontiers have expanded the applicability of existing methods in structural biology and helped close the resolution gaps between them. As a result, we are now poised to integrate structural information gathered at multiple levels of the biological hierarchy - from atoms to cells - into a common framework. The goal is a comprehensive description of the multitude of interactions between molecular entities, which in turn is a prerequisite for the discovery of general structural principles that underlie all cellular processes.

MeSH Terms
Animals Crystallization Humans Microscopy, Electron/methods Models, Molecular Protein Conformation Proteome/chemistry,metabolism Proteomics/methods,trends
Chemicals
Proteome
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sali Andrej
Department of Biopharmaceutical Sciences, and California Institute for Quantitative Biomedical Research, University of California, San Francisco, California 94143, USA.
Glaeser Robert
Earnest Thomas
Baumeister Wolfgang
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
2003-03-13
Pages
216-25
Language
English
Region
England
NLM ID
0410462
Subset
IM
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