Home LiteratureArticle Details
PMID: 1263263 Published · ppublish English Journal Article

Coenzymes as fossils of an earlier metabolic state.

Journal of molecular evolution ·Vol. 7 ·No. 2 ·1976-03-29 ·Pages 101-4

White HB

Abstract

A metabolic system composed of nucleic acid enzymes is proposed to have existed prior to the evolution of ribosomal protein synthesis. Vestiges of these nucleic acid enzymes persist in contemporary coenzymes. This proposal rationalizes the fact that many coenzymes are nucleotides or heterocyclic bases which could be derived from nucleotides.

MeSH Terms
Biological Evolution Coenzymes/metabolism DNA Replication Fossils Genes Paleontology Transcription, Genetic
Chemicals
Coenzymes
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
White H B
References (9)
9 references, click to expand
  1. The evolution of dehydrogenases and kinases.
    CRC Crit Rev Biochem. 1975 Aug;3(2):111-40 PMID: 1100315
  2. On earlier states of the biochemical system.
    J Theor Biol. 1974 Mar;44(1):145-60 PMID: 4207200
  3. Beta structures of alternating polypeptides and their possible prebiotic significance.
    Nature. 1975 Jul 31;256(5516):383-7 PMID: 238134
  4. Chemical and biological evolution of nucleotide-binding protein.
    Nature. 1974 Jul 19;250(463):194-9 PMID: 4368490
  5. A proposed model for interaction of polypeptides with RNA.
    Proc Natl Acad Sci U S A. 1974 Feb;71(2):283-7 PMID: 4521801
  6. Self-organization of molecular systems and evolution of the genetic apparatus.
    Angew Chem Int Ed Engl. 1972 Sep;11(9):798-820 PMID: 4628613
  7. AN APPROACH TO THE EVOLUTION OF METABOLISM.
    Proc Natl Acad Sci U S A. 1963 Mar;49(3):360-6 PMID: 16591058
  8. [Catalytic role for RNA in DNA replication].
    Nat New Biol. 1972 Mar 29;236(65):101 PMID: 4502801
  9. Selforganization of matter and the evolution of biological macromolecules.
    Naturwissenschaften. 1971 Oct;58(10):465-523 PMID: 4942363
Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF01732468
Published
1976-03-29
Pages
101-4
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01732468 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2