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PMID: 126271 Published · ppublish English Journal Article

Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes and monocytes.

The Journal of experimental medicine ·Vol. 142 ·No. 3 ·1975-09-01 ·Pages 773-84

Sullivan JL, Barry DW, Lucas SJ, Albrecht P

Abstract

A study of the susceptibility of human peripheral blood mononuclear cells to measles virus infection and replication is reported. Resting lymphocytes obtained from adults showed very low levels of infection and virus replication while lymphocytes activated by plant mitogens or allogenic lymphocytes supported mononuclear cells obtained from the umbilical cord of healthy neonates were more susceptible to measles virus infection than those of adults; however, activated cord lymphocytes supported viral replication in the range observed with adult activated lymphocytes. Monocytes obtained from adults were relatively resistant to measles virus infection and replication while neonatal cord blood monocytes supported viral replication to the degree observed with activated lymphocytes. It is hypothesized that infection of acitivated lymphocytes may explain the depression of cell-mediated immunity seen during acute measles virus infection. The significance of the finding that neonatal monocytes are more susceptible to viral infection and replication than adult monocytes is discussed.

MeSH Terms
Adult Cell Count Cell Survival Cells, Cultured Concanavalin A/pharmacology Culture Media/analysis Fluorescent Antibody Technique Humans Infant, Newborn Lectins/pharmacology Lymphocyte Culture Test, Mixed Lymphocytes/microbiology Measles virus/pathogenicity Mitogens Monocytes/microbiology Viral Plaque Assay
Chemicals
Culture Media Lectins Mitogens Concanavalin A
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sullivan J L
Barry D W
Lucas S J
Albrecht P
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30 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.142.3.773
Published
1975-09-01
Pages
773-84
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189913
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.142.3.773 PMC Full Text View journal details
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