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PMID: 12624267 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

STAT1-dependent innate immunity to a Norwalk-like virus.

Science (New York, N.Y.) ·Vol. 299 ·No. 5612 ·2003-03-07 ·Pages 1575-8

Karst SM, Wobus CE, Lay M, Davidson J, Virgin HW

Abstract

Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus. Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1-dependent innate immunity, but not T and B cell-dependent adaptive immunity, is essential for norovirus resistance. The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease.

MeSH Terms

Animals B-Lymphocytes/immunology Brain/virology Caliciviridae Infections/immunology DNA-Binding Proteins/genetics,physiology Genes, RAG-1 Genome, Viral Homeodomain Proteins/physiology Immunity, Innate Immunocompromised Host Intestines/virology Liver/virology Membrane Proteins Mice Mutation Norovirus/classification,immunology,isolation & purification,pathogenicity Phylogeny RNA, Viral/analysis Receptor, Interferon alpha-beta Receptors, Interferon/genetics,physiology STAT1 Transcription Factor Spleen/virology T-Lymphocytes/immunology Trans-Activators/genetics,physiology Virulence

Chemicals

DNA-Binding Proteins Homeodomain Proteins Membrane Proteins RNA, Viral Rag2 protein, mouse Receptors, Interferon STAT1 Transcription Factor Stat1 protein, mouse Trans-Activators V(D)J recombination activating protein 2 interferon gamma receptor RAG-1 protein Receptor, Interferon alpha-beta

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Karst Stephanie M

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Wobus Christiane E

Lay Margarita

Davidson John

Virgin Herbert W

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1077905

Published

2003-03-07

Pages

1575-8

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAID NIH HHS · R01 AI49286 · United States

NCI NIH HHS · T32-CA09547 · United States

External Links

PubMed source DOI: 10.1126/science.1077905 View journal details

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STAT1-dependent innate immunity to a Norwalk-like virus.

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