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PMID: 12617740 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Science review: redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for hypoxia-inducible factor-1alpha.

Critical care (London, England) ·Vol. 7 ·No. 1 ·2003-02-00 ·Pages 47-54

Haddad JJ

Abstract

A progressive rise of oxidative stress due to altered reduction-oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription in physiology and pathophysiology. Reactive oxygen species and reactive nitrogen species serve as signaling messengers for the evolution and perpetuation of the inflammatory process that is often associated with the condition of oxidative stress, which involves genetic regulation. Changes in the pattern of gene expression through reactive oxygen species/reactive nitrogen species-sensitive regulatory transcription factors are crucial components of the machinery that determines cellular responses to oxidative/redox conditions. The present review describes the basic components of the intracellular oxidative/redox control machinery and its crucial regulation of oxygen-sensitive and redox-sensitive transcription factors within the context of lung injury. Particularly, the review discusses mechanical ventilation and NF-kappaB-mediated lung injury, ischemia-reperfusion and transplantation, compromised host defense and inflammatory stimuli, and hypoxemia and the crucial role of hypoxia-inducible factor in mediating lung injury. Changes in the pattern of gene expression through regulatory transcription factors are therefore crucial components of the machinery that determines cellular responses to oxidative/redox stress.

MeSH Terms
Animals DNA-Binding Proteins/metabolism Gene Expression Regulation Humans Hypoxia/genetics,metabolism Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Immunocompromised Host/genetics Inflammation/genetics,metabolism Lung Transplantation/adverse effects Mice Nuclear Proteins/metabolism Oxidation-Reduction Oxidative Stress/genetics Respiration, Artificial/adverse effects Respiratory Distress Syndrome/etiology,genetics,metabolism Transcription Factors/metabolism
Chemicals
DNA-Binding Proteins HIF1A protein, human Hif1a protein, mouse Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Nuclear Proteins Transcription Factors
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Haddad John J
Severinghaus-Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, San Francisco, California, USA. haddadj@anesthesia.ucsf.edu
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Article Info
Journal
Critical care (London, England)
Abbr.
Crit Care
ISSN
1364-8535
DOI
10.1186/cc1840
Email
haddadj@anesthesia.ucsf.edu
Published
2003-02-00
Epub
2002-00-14
Pages
47-54
Language
English
Region
England
NLM ID
9801902
PMCID
PMC154109
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1186/cc1840 PMC Full Text View journal details
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