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PMID: 1261623 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Excitatory nature of dopamine in the nigro-caudate pathway.

Experimental brain research ·Vol. 24 ·No. 4 ·1976-02-26 ·Pages 351-63

Kitai ST, Sugimori M, Kocsis JD

Abstract

Inputs from the substantia nigra (SN) to the caudate nucleus (Cd) and the effects of electrophoretic dopamine on Cd neurones were studied in cats anaesthetized with pentobarbitone with intracellular techniques. Single shock electrical stimulation of the SN or the medial forebrain bundle (MFB) induced monosynaptic EPSPs in Cd neurones. Dopamine depolarized Cd neurones and chlorpromazine suppressed the SN or MFB induced EPSPs. Appropriate controls indicate that the drug effects were not artifactual. Some recorded neurones were identified by procion yellow dye injection as the medium-size intrinsic Cd neurones.

MeSH Terms
Animals Cats Caudate Nucleus/cytology,drug effects,physiology Chlorpromazine/pharmacology Dopamine/administration & dosage,pharmacology Dose-Response Relationship, Drug Evoked Potentials Neural Conduction Neural Pathways Neurons/drug effects,physiology Reaction Time Substantia Nigra/physiology
Chemicals
Chlorpromazine Dopamine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kitai S T
Sugimori M
Kocsis J D
References (47)
47 references, click to expand
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Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00235003
Published
1976-02-26
Pages
351-63
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00235003 View journal details
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